Analysis Of Risk Factors For Postoperative Spinal Cord Injury In Patients With Stanford Type A Aortic Dissection Construction Of External Circulatory Simulation Platform For Aortic Dissection

ObjectiveTo discuss and identify the risk factors for postoperative spinal cord injury in Stanford type A aortic dissection patients underwent SUN’s procedure. Methods210 Stanford type A aortic dissection patients underwent Sun’s procedure in Beijing Aortic Disease Center during July 2014 to March 2015. 14 patients had spinal cord injury after surgery. Clinical data and computed tomography angiography(CTA) imaging of aorta were retrospectively analyzed and multi-logistic regression analysis was performed to identify risk factors for Spinal cord injury post operation. Results14 out of 210(6.7%) patients had spinal cord injury after surgery. Univariate analysis showed only false lumen derived intercostal arteries at eighth thoracic vertebral level(T8) to first lumbar vertebral level(L1) was significantly associated with post-surgery spinal cord injury(P < 0.000). Multi-logistic regression analysis showed that false lumen derived intercostal arteries(P = 0.000)and age(P = 0.035) were significantly associated with postoperative spinal cord injury. ConclusionsMajor intercostal arteries derived from false lumen and rapid thrombogenesis in false lumen are the major risk factors for postoperative spinal cord injury in Stanford type A aortic dissection patients. Cerebrospinal fluid drainage remains the most effective way to treat and prevent spinal cord injury. ObjectiveTo construct a pulsatile circulatory platform for aortic dissection,then to perform fluid dynamics testing. MethodsThe physical attribute and structural shape of the aorta were measured, and substitute material for aortic wall was determined; then the bionic aortic model was structured with 3D printing technology; a pulsatile circulatory platform was constructed to perform fluid dynamics testing for aortic dissection, and the properties of the platform were determined. Results(1) Intimal thickness: 1.19 ±0.28 mm, maximum bearing capacity: 12.17±3.78N;(2).The platform showed reliable performance, met the demands of in vitro testing. ConclusionsThe construction of a pulsatile circulatory platform for aortic dissection provides new methodology to investigate the pathogenesis of aorta diseases, the impact of various ways of intubation on branch blood flows, and the simulation of intervention therapy.