| Objective To assess the influencing factors of the progression of carotid atherosclerosis stenosis using color Doppler flow imaging(CDFI). Methods From January 2009 to December 2014, a total of data 279 consecutive patients first assessed by CDFI at 12, 24 and 36 months after initial examination were enrolled retrospectively. The residual diameter of vascular lesions and the change of hemodynamic parameters were documented, and they were divided into either a progression group(n=40) or a non-progression group(n=239) according to whether the degree of stenosis progressed into severe stenosis(stenosis rate 70-99%) or occlusion, and the non-progression group was divided into steady group(n=210) and better group(n=29). The effects of the risk factors for common cerebrovascular disease and taking lipid lowering drugs(atorvastatin 20 mg/d) on stenosis progression were compared in patients between the 2 groups. There were significant differences in hypertension, smoking and the regular use of atorvastatin. The effects of those factors on the progression of carotid stenosis were compared further through Logistic regression analysis. Results The residual vascular diameters of the non-progression group. There was significant difference(all P < 0.05), and both the stenotic sites and distal peak systolic flow velocity ratio were significantly higher than those of the non-progression group(all P <0.05). Among the risk factors for cerebrovascular disease, hypertension(OR, 2. 686, 95% CI 1.120-6.442, P=0.027) and smoking(OR, 2. 265, 95% CI 1.081-4.746, P=0.030) were the major risk factors for affecting the progression of carotid stenosis. Regularly taking atorvastatin was a protective factor of delaying the progression of carotid stenosis(OR, 0.383, 95% CI 0.178-0.827, P=0.015). Conclusions CDFI may objectively evaluate the progression of carotid stenosis. Smoking and hypertension are the independent risk factors for affecting the progression of carotid stenosis. |
PDF Full Text Request