Meta-analysis Of Correlation Between Hot Tea Drinking And Risk Of Esophageal Cancer

ObjectiveTo explore the correlation between hot tea drinking and the risk of esophageal cancer through Meta-analysis.MethodsCollect published cohort studies and case-control studies of hot tea and its effect on the risk of esophageal cancer. Assure the detailed inclusion and exclusion criteria. Abstract and analyze relevant data, explain the results and then report the conclusion. The details are as follows:(1) Retrieval the documents on the relationship between tea and esophageal cancer from 1996 to December,2014.we searched the Pub Med,、EMbase、Web of Science and Cochrane library. “Oesophageal cancer”,“esophageal cancer”,“esophageal neoplasms”,“cancer or neoplasm”,“tea”,“tea drinking” and the combination of these words are the main searching keywords. We checked the documents and their references seriously, we also searched some relevant system evaluations. EMbase retrieval type is Tea and(\’oesophageal cancer\’ or \’esophageal neoplasms\’ or \’esophageal neoplasms\’ or(\’esophageal\’ and \’cancer\’) or(\’ esophageal\’ and \’neoplasms\’)). We research team filtered the results independently according to qualified documentary inclusion standards, then discussed and solved distributions.(2) Observers read the literature titles, eliminated the irrelevant literatures, repetitive literatures, animal testing and some other documents, and further by reading literature contents, eliminating retrospective analysis, similar to literatures published by the same population, ultimately through in strict accordance with the inclusion criteria 9 articles were included in the study and data analysis.(3) Using the STATA SE12.0 software for Meta-analysis. Count data used OR(odds ratio) and 95% CI(confidence interval) as effective evaluation; Continuous variable data used MD(mean difference) and 95% CI as effective evaluation. P means a lot in statistics if it <0.05. Attach importance to heterogeneity between various studies, using the fixed model for meta-analysis if heterogeneity is acceptable;otherwise, using random effects model for meta-analysis instead. Detect the publication bias ofthe research and draw funnel plots. Last but not the least, use the Begg’s method and Egger’s method of STATA SE 12.0 software to detect the publication bias of the research.ResultsThis research adopted 9 documents, which include 3261 esophageal cancer cases. We compared the difference of the risk of illness between drinking hot tea and regular tea, and came to conclusion that hot tea increases the risk of getting a esophageal cancer,(OR=2.21,95%CI( 1.95,2.51), Z=12.50, P<0.00001,Begg’s test :Pr>|Z|=0.858>0.05;Egger’s test :P=0.74>0.05), which indicates that the documents we chosen have no publication bias.ConclusionDrinking hot tea may increase the risk of getting a esophageal cancer. Because of inadequate documents, however, a lot of samples, multi-central cohort studies and case-control studies are still in need in clinic to prove the accuracy of this conclusion.