Diagnostic Values Of Serum Tumor Markers Cyfra21-1, SCCAg, Ferritin, CEA, CA19-9 And AFP In Oral/oropharyngeal Squamous Cell Carcinoma

Background: In recent years, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern.The aim of this study was to investigate the diagnostic values of serum tumor markers Cyfra21-1, SCCAg, Ferritin, CEA, CA19-9 and AFP for patients with oral/oropharyngeal squamous carcinoma(OSCC/OPSCC).Methods: One hundred and sixty-nine cases of patients with OSCC/OPSCC as the experimental group, eighty-six cases of oral benign tumor patients as the control group, thirty cases of healthy people as the normal control group. The levels of serum Cyfra21-1, SCCAg, Ferritin, CEA, CA19-9 and AFP were measured using electrochemiluminescence immunoassay(ECLIA).The data were processed using SPSS21.0 statistical software and the ROC analysis was performed.Results: The levels of serum Cyfra21-1, SCCAg, Ferritin and CEA in patients with OSCC/OPSCC were significantly higher than those of benign tumor group and healthy control group(all P<0.05). The levels of CA19-9 and AFP showed no significant difference between patients with OSCC/OPSCC, benign tumor group and healthy group(all P>0.05); The level of serum Cyfra21-1 in early oral/oropharyngeal squamous carcinoma patients(I + II phases) was significantly higher than that of benign tumor group and healthy control group(all P<0.05). However, the levels of serum SCCAg, Ferritin, CEA, CA19-9 and AFP showed no significant difference between patients with early OSCC/OPSCC, the benign tumor group and healthy control group(all P>0.05);The levels of serum Cyfra21-1, SCCAg, Ferritin and CEA in the middle-late phase of patients with OSCC/OPSCC(III + IV phases) were significantly higher than those of patients with the early OSCC/OPSCC, benign tumor group and healthy control group(all P<0.05); The diagnostic cut-off levels of Cyfra21-1, SCCAg, Ferritin and CEA were 2.17, 0.72, 109.95 and 1.99ng/ml respectively; The sensitivities were 60.36%, 73.37%, 81.66% and 66.27%; The specificities were 81.03%, 68.10%, 40.52% and 61.21%.Conclusion: Among Cyfra 21-1, SCCAg, Ferritin, CEA, CA19-9 and AFP six serum tumor markers, the diagnoses of Cyfra21-1 and SCCAg for patients with OSCC/OPSCC was superior to those of other serum tumor markers. Meanwhile, Cyfra21-1 had better early diagnostic value for patients with OSCC/OPSCC, CA19-9 and AFP had no diagnostic value for patients with OSCC/OPSCC.