Correlation Research Between CyPA、Lp-PLA2 And Unstable Carotid Plaques And ACI

Objective: Atherosclerosis is the pathological basis of cerebral infarction, and unstable plaque formation is a key factor of cerebral infarction, recurrent. Inflammatory reaction participates in the development of atherosclerosis, the unstable plaque formation and rupture. This project aimed to observe the levels of lasma lipoprotein-association phospholipase A2( Lp-PLA2) and cyclophilin A in unstable carotid atherosclerosis plaques with atherosclerosis cerebral infarction patients( ACI group)、simple carotid atherosclerosis in patients with unstable plaques( simple plaques group) and healthy people( control group). To investigate the relationship between the levels of plasma Cy PA、Lp-PLA2, the unstablility of carotid plaque and ACI.Methods: One hundred patients with carotid unstable plaque confirmed by carotid ultrasound,divided into two groups as follows : cerebral infarction group( ACI group, n=50) or not having cerebral infarction( plaque group, n=50). And 50 health subjects over the same period as control. Collect the general information : age, sex,index of body mass index(BIM), smoking history,examined the levels of total cholesterol( TC), Triglycerides( TG), high density lipoprotein( HDL), lowdensity Lipoprotein( LDL),glycosylated hemoglobin( Hb Alc), Homocysteine( HCY), C-reactive protein( CPR)after an overnight fast. The levels of serum Cy PA, Lp-PLA2 were detected by ELISA. Adopt SPSS17.0 software for statistical analysis. Measurement data are expressed as mean ± standard deviation( x ±S), comparison between groups use one-way ANOVA, Equal Varance not assumed use rank sum test, attribute data expressed as a ratio with the chi-square tes. All the indexes of a test as relevant variables, cerebral infarction events occurred as dependent variables analyze the risk factors with logistic analysis.Results: The levels of plasma Cy PA in patients with ACI group( 2.031 ± 0.679 ng/ml) > plaque group(3.790 ± 0.943 ng/ml)> the control group( 5.113±1.568 ng/ml), the difference was statistically significant(P<0.01). Logistic regression analysis showed that Cy PA is the independent risk factors for patients of unstable plaque occurring cerebral infarction( OR= 2.71, 95%CI: 1.52~ 4.83, P=0.01). Correlation Analysis show Cy PA、Lp-PLA2 into positive correlation( r=0.343).Conclusion: Plasma Cy PA、Lp-PLA2 level can be used as a clinical marker of unstable carotid plaques;The serum salusin-α level are possible risk factor for cerebral infarction.Joint detection of Cy PA、Lp-PLA2 could predict the occurence of ACI.