Changes Of Plasma Diamine Oxidase Levels In Multiple-injury Patients And Its Relation With Gastrointestinal Dysfunction

Objectives:To explore the relationship between gastrointestinal dysfunction and the level of plasma diamine oxidase(DAO) in patients with severe multiple trauma.Methods:48 patients with severe multiple trauma were divided into mild injury group(ISS score <16 score,26 cases) and severe multiple injury group(ISS score >16 points, 22 cases) according to ISS sore.another 20 healthy people served as the control group.Venous blood was collected for 1 time in the control group and in other groups venous blood were collected in 24 h, 120 h and 72 h. The concentration of plasma DAO was measured by enzyme-linked immunosorbent assay.Results:For the detection data of plasma DAO, there was significant interaction between time factor and treatment factor(P<0.01). Compared with the control group the DAO levels in the mild injury group and the severe injury group were both increased obviously in 24 h after trauma(P<0.01),and were higher in the severe injury group than in the mild injury group(P<0.01). Gradually the DAO level decreased and recovered to normal in 120 h after trauma in the mild injury group, but DAO level was significantly higher the severe group than that in thel control group(P<0.01). The level of plasma DAO were both highly relevant to the degree of gastrointestinal dysfunction in24 h, 72 h, 120 h.Conclusions:The results suggested that the Change of the the level of plasma DAO not only relevant to the severity of trauma, but also closely to the degree of the gastrointestinal dysfunction.The observation of change of plasma DAO level maybe effective to predict the gastrointestinal dysfunction after severe trauma.