Effects Of Interleukin-1 Beta Genetic Polymorphism And Childhood Maltreatment On Antidepressant Treatment In Major Depressive Disorder

Background:To explore the affecting factors of curative effect of antidepressant and to improve the low curing rate of antidepressant based on varying treatment for different individual. Researches within decades revealed the observation that functional polymorphisms in the promoter region of regulatory genes predict phenotypes of interest in interaction with predisposing behavioral orbiological factors.As several researches have shown, children trauma may increase the morbidity of major depression disorder and affects the curative effect of antidepressant. Others suggest that inflammatory process contributes to the pathophysiological procedure of depression and also affects the effects of antidepressant.Objective: To discuss the influence on antidepressant response of depression from the polymorphisms of interleukin 1B gene and environmental factors.Method: A group 204 Chinese Han patients received one single antidepressant drugs and followed up for at least 6 weeks. The Hamilton depression scale-17 (HAMD-17) was used to evaluate the severity of depressive symptoms and the therapeutic effects. Childhood trauma questionnaire-short form (CTQ-SF) was used to evaluate the quantity of stimulus of childhood trauma and other subscales. The single nucleotide polymorphism (SNP) of promoter region of interleukin 1B gene (rs 16944) was choose to apply multiplex SNaPshot. T-test and Pearson’s x2 Test were applied to CTO scale value and general information in 8 weeks from cured group and uncured group using SPSS 20.0. The relevance between selected gene locus and the effect of antidepressant was analyzed using Unphased 3.0.13. The x2-test was applied to analyze the differenceof childhood trauma of different gender using SPSS 20.0;The influence of childhood trauma total items and each sub items to the severity of depression and the effect of antidepressant was analyzed using Person correlation analysis. The influence on the effect of antidepressant from the interactive effect of gene and environments was analyzed using logistic regression.Result:No significant differences to the 8 weeks of clinical information from cured group and uncured group. The analysis of drug gene association discovered that AA genotype carrier on ILIB gene rs 16944 gene locus has relatively low cure effects of antidepressant (x2=3.931, P=0.047) compare to AG, GG genotype carrier. The correlation was more significant in SSRI subunit. No significant differences between different genders of childhood trauma experiences, the analysis of childhood trauma experiences and each item and effects of antidepressant shows no significant correlation. The mutual analysis between gene and environments shows that the interactive effect between AA genotype on ILIB gene rs16944 locus and severe childhood trauma has correlations with lower curing rate of antidepressant. (P=0.043).Conclusion: Childhood trauma may not be the sole factor that affects the effect of antidepressant,but we found that depressed patients experiencedchildhood traumashowed a significantly earlier age of onset of depression (6 years) comparedwith depressed subjects whodidn’t.the interactive effect of polymorphism of ILIB gene s16944 locus and childhood trauma may affects the curing of depression patients.