The Study Of Immune Reconstitution After Hematopoietic Stem Cell Transplantation

ObjectiveTo discuss how different subsets of the lymphocytes recover,meanwhile the influence factors were also studied.MethodsThe different level of peripheral blood CD4+T cells, CD8+T cells, NK cells% B cells from 40 patients who recieved hematopoietic cell transplantation and 20 normal people were detected by flow cytometer.We analyzed lymphocytes at 1 month, 3 months,6 months and 1 year after transplantation.ResultsThe absolute number of lymphocytes recover quickly after transplantation;the NK cells come back to normal at 1 month;B cells count recover at 6months; the B cells rcover slower in the patients who received haploidentical HCT; CD4+T cell counts was lower in cytomegalovirus seropositive patients; naive CD4+T cell reconstitution after ATG-conditioned HCT was slower.ConclusionThe immune system is damaged after HSCT,different lymphcytes subsets recovery has its own characteristics.The immune reconstitution affected by many factors.