Comparison Of Clinical Application Between Intravascular Ultrasound And Fractional Flow Reserve In Appraising The Intermediate Coronary Artery Disease

Objective:To evaluate the clinical outcomes of fractional flow reserve (FFR)-guided versus intravascular ultrasound (IVUS)-guided treatment for intermediate coronary lesions.Method:A total of 133 patients with intermediate coronary artery lesions (stenosis of 50%- 75%) confirmed by coronary angiography were included into the research from July 2013 to October 2013 in Southeast university affiliated Zhongda hospital.133 patients were divided into 2 groups in which patients underwent FFR (n=57) and IVUS (n=76) guided treatment respectively.2 groups were compared in the target vessels, clinical biochemical indexes and long-term outcomes. The long-term outcome was major adverse cardiac events including cardiac death, myocardial infarction, and ischemia-driven target vessel revascularization after 12 months.Results:The baseline of percent diameter stenosis of CAG, target vessels and biochemical indexes was similar between the 2 groups. FFR group showed significant relation between FFR and certain coronary artery disease relating biochemical indexes. IVUS group showed no significant relation between Minimum lumen area (MLA) and any coronary artery disease biochemical indexes. Moreover more percent of patients in IVUS group (37%) received PCI compared with FFR (16%) group (P<0.05). No significant difference was found in the incidence of major adverse cardiac events and the angina rate between the 2 groups (p>0.05).Conclusions:1. FFR could efficiently predict the severity of intermediate coronary artery lesions.2. FFR group has lower PCI rate compared with IVUS group.3. FFR group has the similar rate in both major adverse cardiac events and angina compared with IVUS group.4. FFR could decide whether an intermediate coronary lesion should accept PCI.