Correlation Research Between High-sensitivity C-reactive Protein, Interleukin-6,Tumor Necrosis Factor-alpha And Coronary No-reflow

Objective: To investigate the correlation between high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and coronary no-reflow in patients with acute coronary syndromes(ACS).Methods: A total of 90 patients in the department of Cardiology Affiliated Hospital of Yan’an University with acute coronary syndrome(ACS) were all treated by percutaneous coronary intervention(PCI), the patients those intraoperative appear no reflow were in test group(n=30), use random choice method selected those patients also treated by PCI and not appear no reflow in the same period in our hospital as control group(n=60).Collecting venous blood 3milliliter of those patients to detect plasma hs-CRP, IL-6,TNF-α levels respectively in patients with preoperative and postoperative 24 hours,analysis of the concentration on those three factors of preoperative and postoperative of two group patients. Using the receiver operating characteristic(ROC) curve to analysis the relationship between plasma hs-CRP, IL-6, TNF-α levels and no reflow of patients with ACS. Pearson analysis was used to observe the correlation between every two factors of plasma hs-CRP, IL-6, TNF-α with the patients of ACS. Using multiple logistic regression analysis to observe if the plasma hs-CRP, IL-6, TNF-α levels can well predict the coronary no reflow occurrence.Results:1.The test group patients plasma hs-CRP, IL-6, TNF-α levels significantly higher than the control group(P<0.05), the difference is statistically significant. The test group patients plasma hs-CRP, IL-6, TNF-α levels postoperative higher than preoperative(P<0.05), the difference is statistically significant. The control group patients plasmahs-CRP, IL-6, TNF-α levels postoperative and preoperative has no obvious change(P>0.05), there was no statistically difference.2.Receiver operating characteristic(ROC) curve analysis revealed, that the area under the curve(AUC) of plasma hs-CRP(ROC area 0.686, P<0.05), plasma IL-6(ROC area 0.740, P<0.05), plasma TNF-α(ROC area 0.725, P<0.05).3.Pearson analysis revealed, that plasma hs-CRP, IL-6, TNF-α levels, the correlation between every two factors(0.7<r<1,P<0.05).4.Using multiple logistic regression analysis, plasma hs-CRP levels(OR 2.338,95%CI 1.300-4.205, P=0.005) were found to be a significant risk factor of coronary no-reflow together with plasma IL-6 levels(OR 1.042, 95%CI 1.015-1.070, P=0.002)and plasma TNF-α levels(OR 3.701, 95%CI 1.432-9.566, P=0.007).Conclusion:1.The plasma hs-CRP, IL-6, TNF-α levels of patients with ACS after PCI has certain relevance with coronary no-reflow.2.There was a highly positive correlation between the plasma hs-CRP, IL-6, TNF-αin the patients appear no reflow.3.Monitor the inflammation factor hs-CRP, IL-6, TNF-α to predict coronary no-reflow is feasible.