The Effect Of Epidural Injection Of Dexamethasone On The Efficacy Of Dezocine Analgesia After Cesarean Section

Objective: To observe the effect of epidural injection of dexamethasone on the analgesic efficacy of dezocine in patients after cesarean section.Methods: The subjects were sixty patients(ASAI~II) at the age of 20 to 35 undergoing cesarean section during the period from March to June 2015 in Yan’an University Affiliated Hospital. The patients were randomly individe into two groups. The patients in dexamethasone group were received epidural 4 mg dexamethasone(dilutes with 0.9% normal saline 4 m L to 5 m L), and these in control group were received epidural 0.9% normal saline 5 m L when fetal profile. Two groups were underwent surgery under vombined spinal epidural anesthesia. All the patients were keptkeep in left lateral position when anesthesia, epidural injected 0.75% bupivacaine 1.5 m L dilutes with cerebrospinal fluid and hypertonic glucose solution 0.1 m L to 3 m L. Then the half was administered to the patients. At the end of surgery, all the patients were sent to the anesthesia recovery room. Observed indicator:(1)The total dezocine consumption in two days after the operation;(2) Side effects:such as low back pain, itching, vomiting,headache, nausea, etc;(3)Pain score: VAS scoring was recorded at 6, 12, 24, 48 h after the end of surgery;(4)The levels of white blood cells and plasma C-reactive protein value in the second days after operation.Results: 1. The VAS scores at 6, 12 h after operation were lower in dexamethasone group than they in control group B, and the differences was statistically significant(P<0.05). There were no significant differences in the VAS scores at 24, 48 h in the two groups after operation(P>0.05).2. There was significant decrease in postoperative dezocine consumption during the first 48 h in the dexamethason group compared with control group(P<0.05)The postoperative dezocine consumption during the first 48 h was significantly decreased in dexamethasone group compared with the control group(P<0.05). 3. Postoperative low back pain was significantly lower in the dexamethasone group than it in the control group(P<0.01). No other side effects happen. 4. The levels of white blood cells and C-reactive proteinin the second days after operation were significantly increased in the dexamethasone group compared with the control group(P<0.01). But all were the normal range. 5. Side effects and patient satisfaction scores had no significant difference between dexamethasone group and control group(P>0.05)Conclusion: 1. Epidural administration of dexamethasone 4 mg reduces postoperative dezocine consumption. 2. Epidural injection of dexamethasone 4 mg reduces the incidence of postoperative low back pain, and doesn’t increase the risk of adverse reactions after operation.