The Role Of Endothelial Microparticles In Systemic Lupus Erythematosus

Objective:In a prospective observational study, we investigated whether patients with systemic lupus erythematosus(SLE) had higher indices of endothelial damage and dysfunction than healthy controls and whether endothelial was associated with SLE disease activity and the detection of thrombosis and kidney involvement.Methods:40 patients with active SLE(four or more American College of Rheumatology(ACR) criteria and 22 age-matched controls were assessed. Endothelial microparticles(EMPs; CD31+/CD42b-) were quantified using flow cytometry.Results:1. Plasma levels of CD31+/CD42- EMP is higher in patients with SLE compared to controls(both ?< ?0.05).2.The levels of CD31+/CD42- EMP in SLE with quantity of 24 hour urine Protein greater than orequal to 0.59/24 h higher than that in those less than 0.59/24 h.(P=0.000<0.05).3. The levels of CD31+/CD42- EMP in the active SLE(SLEDAI scores>10) Patients higher than That in the inactive SLE patients(SLEDAI scores>10)4.SLE with lupus nephritis and thrombus with an increased hyperemia index was observed,While there are no statistieal significance In those with clinica symptom as asarthritis,dental uleer,hand vaseulitis,Pulmonary hypertension and digestive system impairmen4. Levels of CD31+/CD42- EMP were significantly increased in patients withβ-GP1+ compared to patients withβ-GP1-(P=0.000<0.05).5. A strong association could be demonstrated between CD31+/CD42- EMP and D – dimer、 SLEDAI scores.(Spearman,r=0.78,P=0.000<0.05;r=0.78,P=0.000<0.05), while no relationships are found with Ig G,Creaetive Protein(CRP).Conelusion:EMP indicate molecular vascular damage in SLE;in this study a strong association between EMP and SLEDAI scores; EMP may be a potential marker benefitting the diagnosis and therapy monitoring of patients with SLE with associated lupus nephritis and thrombus.