Analysis In Risk Factors And Diagnosis Of Anterior Ischemic Optic Neuropathy

Objective:The risk factors and clinical diagnosis of nonarteritic anterior ischemic optic neuropathy(NAION) will be investigated.Methods:For patients who presented to First Hospital of Shanxi Medical University with NAION between 2014 and 2015, fundus fluorescein angiography(FFA), visual field,visual evoked potential(VEP) and colour Doppler ultrasonography examination, blood pressure, blood glucose and blood lipid examination were possible on 44 eyes of 42 patients, 30 eyes of 30 patients were enrolled as control. Age of patients ranged from 42 to71 years(mean 55.43 ± 8.03 years).Results:In the NAION group compared with the normal group, carotid artery diseases, age,hypertension, hyperlipidemia, the differences were statistically significant(P<0.05); there was no significant difference in gender, diabetes and smoking(P>0.05). In early FFA, all of 44 eyes showed fluorescence filling of the optic disc were delayed or defect, while advanced performances were different; In the examination of visual field 37 eyes(84.09%)were connected with the physiological blind spot scotoma; In VEP abnormal amplitude ratio(92.50%) of P100 was significantly higher than that of the incubation period(67.50%),NAION patients group compared with healthy eyes group and control group, incubation period of P100 was prolonged and the amplitude decreased(P<0.05), the healthy eyesgroup compared with the normal group,the incubation period of P100 was extended(P<0.05); carotid artery color Doppler ultrasound abnormality rate(61.09%) was higher,the NAION group compared with the control group, IMT increased, the internal carotid artery peak systolic velocity(PSV) and end diastolic velocity(EDV) decreased(P<0.05),but resistance index(RI) value was increased(P<0.05), while healthy eyes group and the NAION group had no statistical difference(P>0.05).Conclusions:NAION is related to multiple factors, especially associated with carotid artery disease,hypertension and hyperlipidemia. FFA and visual field have high value in the diagnosis of NAION, but the performances are complex. Carotid artery color Doppler ultrasound and VEP also have obvious anomaly, so they can provide a new direction for clinical early diagnosis and intervention.