Prognosis Predictive Value Of The Combination Of HsCRP And Cys-C On Acute Myocardial Infarction Patient

Objective (s):Researching the Prognosis predictive value of the combination of hsCRP and Cys-C on acute myocardial infarction patients.Methods:Setting the 170 acute myocardial infarction patients of affiliated Calmette International Hospital of Kunming Medical University from Jun.,2014 to Jan.,2015, According to the exclusion criteria,17 patients were excluded,30 patients were lost to follow-up, and 123 patients were selected.Among which there are 107 acute myocardial infarction patients with ST-segment elevation and 16 acute myocardial infarction patients with non-ST-segment elevation. All of them are treated by coronary angiogram-emergency PCI treatment and tested cTnT, TC, LDL-C, HDL-C, hsCRP, Cys-C as well as blood and urine test regularly after entering the hospital. Then dividing the 123 acute myocardial infarction patients into 4 groups according to the test results of concentration levels of hsCRP and Cys-C, namely A group:22 patients with normal hsCRP and Cys-C; B group:31 patients with higher hsCRP and normal Cys-C; C group:33 patients with normal hsCRP and higher CysC: and D group:37 patients with higher hsCRP and Cys-C. The following conditions are excluded:severe hepatic and renal dysfunction, valvular heart disease, specific dominance congestive heart failure, connective tissue disease, malignancy, infection, injury and chronic obstructive pulmonary disease. Following-up and researching the illness state of patients in hospital and patients’ conditions after leaving hospital regularly for 6 months while recording the occurrence of cardiovascular events (malignant arrhythmia, cardiac death, recurrence myocardial infarction, recurrence stenocardia, and recurrence cardiac failure). Dividing patients into groups according to whether he/she has cardiovascular event. Finally, comparing the prognosis conditions of the four groups’ patients, as well as analyzing the recovery status and development conditions of patients after leaving hospital.Results:(1) Patients with higher hsCRP and Cys-C have higher risk in occurring cardiovascular events than patients with higher hsCRP and normal Cys-C and patients with normal hsCRP and higher Cys-C; patients with higher hsCRP and Cys-C have higher risk in occurring cardiovascular events than patients with normal hsCRP and Cys-C; patients with higher hsCRP and normal Cys-C have higher risk in occurring cardiovascular events than patients with normal hsCRP and Cys-C; patients with normal hsCRP and higher Cys-C have higher risk in occurring cardiovascular events than patients with normal hsCRP and Cys-C; the cardiovascular events occurrences of patients with higher hsCRP and normal Cys-C and patients with normal hsCRP and higher Cys-C has no significant difference. (2) The analysis results of single factor show that:age, sex, diabetes, troponin, killip classification, hsCRP and Cys-C has positive relation with the prognosis of acute myocardial infarction patients, while LVEF has negative relation with the prognosis of acute myocardial infarction patients. (3) Setting the occurrence of cardiac events as dependent variable, and setting age, sex, diabetes, troponin, killip classification, hsCRP, Cys-C and LVEF as independent variables, then conducting Logistic regression analysis. It can be found that age, hsCRP, CysC, LVEF (%), and diabetes have the most closed relationship with cardiac events (p<0.05).Conclusion(s):The combination of hsCRP and CysC has relative high clinical value in the prognosis of acute myocardial infarction patients after PCI method.