Clinical Factors Analysis Of Pancreatic Cystic Disease

Objective:to explore the associated clinical factors and the qualitative diagnosis on pancreatic cystic disease.Methods:Retrospective analysis was made on the clinical data of 41 cases of pancreatic cystic disease from June January 2006 to December 2015 in the first affiliated hospital of kunming medical university.the pathological types of 41 cases is confirmed after surgering, but these case were not clear qualitative diagnosis before the operation. The clinical Statistics include the patient’s gender, age, symptoms (atypical abdominal pain, asymptomatic), the serum tumor markers CEA and CA19-9, CT manifestations (neoplasms’size, location, and presence of solid components and coanda nodules). The pancreatic cystic diseases were discussed by dividing into benign and malignant groups. Using single factor analysis of SPSS 17.0 statistical software for data, after single factor analysis of the possible related factors multiariable Logistic regression analysis. Has statistical significance (P< 0.05) saidResults:Postsurgical pathology revealed 27 cases with benign,14 cases with malignant.The pseudocyst, chronic pancreatitis retention cyst, lymphatic epithelial cyst 1 case of each item, serous cystic adenoma 9 cases (21.9%),10 cases of mucous cyst adenomas (24.3%),5 cases of intraductal papillary mucinous tumor (12.1%), solid false papilloma,4 cases (9.7%) mucinous cystadenocarcinoma 9 cases (21.9%), intraductal papillary mucinous carcinoma in 1 case (2.4%). The average age of malignant group was 59.71 ±6.92 (49-71), however benign group was 42.18± 14.53 (19-65). the malignant group were significantly older than that of benign group (P= 0.000).30 patients (73.2%) have one or more symptoms, such as atypical abdominal pain 25 cases (68.2%), jaundice (2 cases), abdominal mass found (3 cases), thin (2 cases); Univariate analysis shows that symptomatic of pancreatic cystic disease (P= 0.192) and atypical abdominal pain (P= 0.231) were not significant relationship with pancreatic cystic malignant tumor。 The elevating serum tumor markers CA1998 cases in benign group (29.6%) compared to malignant group 9 cases (64.3%), (P= 0.033). The diameter of tumor was 4.21±1.52cm(2-10.5 cm), more than 3 cm in benign disease group 14 (51.9%), less than 3 cm in malignant diseases group 13 cases (92.9%) (P= 0.009). Cyst with solid component or attached to the wall nodules in benign group 2 cases (7.4%),7 cases of malignant group (50%), P= 0.002).The location distribution is no significant correlation with benign and malignant tumor。 Multi-factor analysis show that capsule containing solid ingredients or attached to the wall nodule (P= 0.024) is as the independent risk factors for the development of malignant pancreatic cystic disease.Conclusion:It is difficult to identify the nature of pancreatic cystic disease (CLP) before operation, however pancreatic cystic tumor (SPN) accounted for the vast majority of proportion; Age, elevating serum levels of CA19-9, diameter greater than 3 cm, imaging showed cyst with solid ingredients or attached to the wall nodule were associated with malignant CLP。 The capsule contains solid ingredients or attached to the wall nodule is as independent risk factor.