| [Objective]On the basis of buildingthe model on rabbit that scoliosis with cervical noncommunicating syringomyelia,combined with imaging to observe the pathological process of the changesabout cerebrospinal fluid circulation state, investigatethe effect and significance of the changesof intraspinal cerebrospinal fluiddynamics in scoliosis and with cervical noncommunicating syringomyelia.[Methods]A total of 90 healthy Japanese big earrabbits,25% of kaolin was injected into the parenchyma and central canal of the spinal cord at C-7 with stereotaxic instrument, buildingthe model on rabbit that scoliosis with cervical noncommunicating syringomyelia,dynamic observation the conditions of occurrence and progress about scoliosisby X raypre-building,after the 4th week,6th week,8th week,10th week,12th week,and at the same time,dynamic observationchangesof cerebrospinal fluid(CSF) flow velocity by Phase Contrast cine Magnetic Resonance Image(PC-cine MRI),divided into the experimental rabbits syringomyelia with scoliosis Group (Group A), scoliosis Group (Group B), syringomyelia (Group C) and neither syringomyelia without scoliosis (Group D) after the 12th week., The changes of CSF flow velocity and scoliosis statistical analysis was applied by SPSS 19 software.Comparison between groups with paired T test, the changes of CSF velocity with scoliosis by Spearman correlation analysis[Result]After buildingmodel the 12th week,10 rabbits death,80 rabbit as experimental observation and determination object.There were 0 (0%),23 (28.75%),48 (60.00%),57 (71.25%) that were development ofsyringomyelia after building the 4th week,6th week,8th week,10th week,12th weekin 80 rabbits; And there were 0(0%),26(32.50%),49(61.25%),59(73.75%),59(73.75%) that were development ofscoliosis after building the 4th week,6th week,8th week,10th week,12th weekin 80 rabbits;After the 12th week,there were44 rabbits (55.00%) development of scoliosis with syringomyelia in Group A,15 (18.75%) only development of scoliosis in Group B,13 (16.25%) only development of syringomyelia in Group C,8 (10.00%) neither syringomyelia without scoliosis in Group D. The Group A Cobb’s were 0°,0°,3.2±3.8°,10.3+6.8°,19.3±7.7 °,25.8±8.4°; The Group B Cobb’s were 0°,0°,3.0±3.4°,9.0±4.5°,14.8 ±3.5°,19.2±2.9°. After building the 4th week,6th week,8th week,10th week,12th week,the FM and C7 level CSF VUmax and VDmax reduced gradually,and frompre-building to 4th week,4th week to 6th week, the decline of the CSF VUmax and VDmax is especially evident;From 6th week to 8th week and 8th week to 10th week,the decrease extent reduces gradually;There were no obvious change from 10th week to 12th week. The FM and C7 level CSF VUmax and VDmax had fewer changes after building.Group A and Group B, Group C, Group D cerebrospinal fluid VUmax and VDmax pairwise comparison,Group A and Group B, Group A and Group Cdifference was statistically significant(P< 0.05) on the 10th week,Group A and Group D, Group B and Group D, Group C and Group Ddifference was statistically significant(P< 0.05),but Group B compared with Group C,there was no statistically significant difference (p> 0.05). Group A compared with Group B of scoliosis, the difference was statistically significant (P< 0.05).Group A FM and C7 levels CSF VUmax and VDmax compared with scoliosis progress, has significant correlation (P< 0.01); Group BFM and C7 levels CSF VUmax and VDmax compared with scoliosis progress, has significant correlation (P< 0.01).[Conclusion]1. In the scoliosis with cervical noncommunicating syringomyelia rabbit model,continuous CSF flow velocity decreased will effect the occurrence and development of scoliosis with/or cervical noncommunicatingsyringomyelia;2. In the scoliosis with cervical noncommunicating syringomyelia rabbit model,continuous CSF flow velocity decreased is closely related to the occurrence and development of scoliosis with/or cervical noncommunicating syringomyelia;The different CSF velocity changes may lead to different pathological outcomes.3. In the scoliosis with cervical noncommunicating syringomyelia rabbit model,continue to reduce CSF flow state is closely related to the progress of scoliosis;4. In the scoliosis with cervical noncommunicating syringomyelia rabbit model,CSF velocity changes, syringomyelia and scoliosis influence each other,but in a certain time point had no progress tendency;... |
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