| Objective:Clinical observation of fuzheng capsules contrast megestrol treatment of lung cancer in clinical efficacy and safety of fatigue.Research methods:This study is based on cancer-related fatigue of the existing research results, the 52 patients with lung cancer-related fatigue according to the method of random numbers were randomly divided into the fuzheng capsule group and megestrol group, using questionnaire and venous blood specimen collection way, FACIT-F scale were observed before and after treatment of patients and patients with cartesian ratings, appetite, pain score, serum albumin values and T cell subgroup values, IL-6, CRP value, symptoms and adverse reactions of traditional Chinese medicine, etc. by using the software of EXCEL and SPSS22.0 statistical software for statistical analysis of data.Results:(1) The FACIT-F scale score comparison:the fuzheng group after treatment FACIT-f, physical condition, fatigue additional attention increased obviously (P< 0.05), the megestrol group after treatment FACIT-F, fatigue additional focus on higher than before treatment (P< 0.05). Compared the two groups after treatment, the fuzheng group the FACIT-f, physical condition, fatigue additional attention were higher than megestrol group obviously, the difference was statistically significant (P< 0.05); Social and family status, emotional state, functional status has no significant difference (P> 0.05). (2) The comparison of traditional Chinese medicine symptom integral effect:fuzheng group in 8 cases were markedly effective (30.8%), stable and 14 cases (53.8%),4 cases were ineffective (15.4%); Megestrol group 2 cases had marked effect(7.7%), stable in 13 cases(50.0%), invalid 11 cases(42.3%), between the two groups, there was statistically significant difference (P< 0.05). (3) The KPS and NRS score comparison:the fuzheng group KPS score compared with before fuzheng group and megestrol group after the treatment, were increased significantly (P< 0.05); Fuzheng group and megestrol group after treatment NRS score had no significant difference (P> 0.05). (4) Improve appetite situation:the fuzheng group 8 cases were markedly effective(30.8%),13 cases of stable(50.0%), invalid in 5 cases(19.2%), the megestrol group,20 cases were markedly improved (76.9%)stability in 3(11.5%),3 had no effect(11.5%), the difference between the two groups was statistically significant (Fisher value=11.893, P=11.893< 0.05). (5) Weight comparison:the fuzheng group 3 cases had marked effect(11.5%),14 cases of stable(53.9%), invalid 9 cases(34.6%), megestrol group 19 cases were markedly effective(73.1%),4 cases were stable(15.4%), invalid 3 cases(11.5%), the overall effectiveness is not all equal between the two groups (Fisher value=11.933, P=0< 0.05). (6)T lymphocyte subgroup index comparison: fuzheng group total T cell, CD4+, CD4+/CD8+ratio and NK cells increased significantly (P < 0.05), and CD8+value decrease was not significant (P> 0.05). Compared with the megestrol group after treatment, CD4+, CD4+/CD8+ratio and NK cells increased (P< 0.05), total T cells and CD8+value no significant change (P> 0.05). (7) Peripheral blood as contrast and IL-6:CRP and IL-6 fuzheng group was obviously lower (P< 0.05), albumin, elevated white blood cell and hemoglobin was not significant (P> 0.05). Megestrol group increased CRP was not significant (P> 0.05), albumin, elevated levels of white blood cells, HGB apparent, IL-6 reduced (P< 0.05). Two groups of comparison, CRP, high white blood cells in the fuzheng group (the megestrol group (P< 0.05). (8) Security contrast:24 cases of fuzheng group has no adverse reaction(92.3%), grade 2 in 1 case(3.8%), grade 3 in 1 case(3.8%). Megestrol group without adverse reactions 21 cases(80.8%), grade 2 in 3 cases (11.5%),grade 3 in 2 cases(7.7%), two groups there was no statistically significant difference compared with (Fisher value=1.543, P= 0.502> 0.05).Conclusion:The fuzheng capsule may improve cancer patients by increasing the body’s immune fatigue symptoms, megestrol by promoting protein assimilation and cut the mechanism of inflammatory cytokines and to a certain extent, improve the patient’s appetite, relieve fatigue, but the fuzheng capsule than megestrol on improving fatigue symptoms in patients with cancer curative effect is better, has a certain clinical value. |
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