Clinical Study Of Traditional Chinese Medicine Colon Dialysis And Hemodialysis To Remove Uremic Toxins

In recent years, epidemiological survey found that chronic kidney disease (chronic kidney disease, CKD) incidence rate showed an increasing trend year by year, and progress to the final complications and mortality of patients with end-stage renal disease (end-stage renal disease (ESRD) has increased year by year. At present, it is thought that [1], with the deteriorating renal function of chronic kidney disease patients, toxin reduced ability to remove especially once patients progress to end-stage kidney disease stage and uremic toxin accumulation in the body, a serious threat to the life and health of the patient. In patients with chronic kidney disease in the continued accumulation of uremic toxin is an important pathogenic factor in the disease progression of, so the removal of uremic toxins, especially protein binding toxin scavenging effect is always a hotspot in the research of chronic kidney disease. CKD patients progressed to end-stage renal disease stage,, Hemodialysis (HD) is an important renal replacement therapy in patients with ESRD, and found that the effect of hemodialysis on uremic toxin removal is good. Chinese herbs colon dialysis is in recent years to the early stage of CKD treatment of clinical application of the new method, a large number of studies confirmed [2], Chinese herbs colon dialysis can not only removal of uremic toxins, especially in improve the patient’s clinical symptoms effect significantly.Objective:Indoxyl sulfate (IS) is a protein binding toxin, which has clear cardiac and renal toxicity. Traditional Chinese medicine (TCM) colon dialysis is the early stage of CKD patients treatment and hemodialysis is the main treatment for ESRD patients. Chinese herbs colon dialysis and hemodialysis can clear uremic toxins, but two kinds of ways to treat clear toxins, in particular protein binding toxin is related to clinical research less. So this paper points for CKD stages 3 to 5 non blood dialysis of Chinese herbs colon dialysis and eventually end-stage renal disease in hemodialysis two direction of ckd3-5 period all patients treated ex vivo indoxyl sulfate, indoxyl sulfate correlation with other uremic toxin observed herbal colon dialysis and hemodialysis on uremic toxin removal, especially observed for two kinds of treatment on protein binding toxin clearance levels change..Methods:Hemodialysis group selected has been in our hospital blood purification center dialysis time more than three months of 30 cases of hemodialysis patients, conventional ckd5 foundation treatment, regular treatment of HD 3 times/week, every dialysis time for 4 hours, dialysis process in a stable condition, in which a HD patients before and after the patient’s blood 3ml. Traditional Chinese medicine (TCM) colon dialysis group selected 15 cases of patients hospitalized in our hospital nephrology ward of CKD 3-5, non blood dialysis, foundation treatment of CKD, and for patients of syndrome differentiation of traditional Chinese medicine on the treatment and be kidney internal medicine of traditional Chinese medicine enema (rhubarb, oysters, Flos Sophorae, Herba Taraxaci, snow in June, Radix Aconiti Lateralis Preparata) traditional Chinese medicine (TCM) colon dialysis therapy, colonic dialysis for 3 times/week, each solution retention time is 2-4 hours, were observed for 2 weeks, before and after extraction in patients with colon dialysis with Chinese traditional medicine blood 3ml.Observed in patients with colon dialysis medicine and hemodialysis group toxins include urea nitrogen (BUN), serum creatinine(Scr), uric acid, cystatin C(CysC), homocysteine(HCY) and indoxyl sulfate(IS) to clear the level. Data processing using SPSS 17.0 statistical software to P> 0.05 considered statistically no significance difference, P<0.05 was considered statistically significant difference, with P<0.01 was considered significant difference statistically significant.Results:(1) This study found that the concentration of IS in CKD patients was significantly higher than normal, serum IS CKD patients with Scr, BUN, UA showed a positive linear correlation with the CysC, HCY found no linear correlation.(2) Chinese medicine colon dialysis patients after treatment Scr, Cys C, HCY, IS decreased compared with before treatment, there are significant differences (P<0.05), but BUN, UA around treatment no statistically significant difference (P>0.05).(3) Blood dialysis patients after dialysis kt/V value is greater than or equal to 1.20, uremic toxin levels after hemodialysis in dialysis patients compared with those before treatment was significantly decreased, and toxin levels before and after dialysis is, no statistical difference (P>0.05).(4) Hemodialysis Scr, BUN, UA, Cys C, HCY clearance rate was significantly better than medicine colon dialysis group, a statistically significant difference (P<0.05), while traditional Chinese medicine group IS colon dialysis clearance rate was significantly higher than blood dialysis group was statistically significant (P<0.05).Conclusions:This study showed that the IS as a protein binding rate of 85% of small molecular uremic toxin, patients with CKD other uremic toxins Scr, bun, UA is significantly and positively related to, its toxic effects on the heart and kidney, affecting the long-term prognosis of patients with CKD. Through the observation of hemodialysis with traditional Chinese medicine (TCM) colon dialysis on uremic toxin clearance levels change. This study found that HD can significantly the Scr, BUN, UA small molecule toxin and CysC in molecular toxin clearance, but of indoxyl sulphate (is) toxin removal company. Traditional Chinese medicine colon dialysis can also remove uremic toxins, especially traditional Chinese medicine colon dialysis may be through inhibiting the production and absorption of IS, enhance the intestinal excretion of IS, thereby reducing the level of IS in patients with CKD. Therefore, hemodialysis and medicine colon dialysis can remove uremic toxins, thereby improving the clinical symptoms of CKD patients, delaying the process of life in patients with CKD. Chinese medicine can be colon dialysis promote clearance of toxins and reduce the accumulation of uremic toxins on kidney damage and prolong into the hemodialysis treatment time, there is a high clinical value for patients with non-dialysis CKD early and mid-stage. Hemodialysis patients with end-stage renal clearance of uremic toxins, its small molecular uremic toxins fully clear, but IS clear is not ideal, but IS toxin toxic effects on the heart and kidney, so ESRD patients with intermittent hemodialysis TCM colon dialysis may help remove toxins is toxin binding protein level, in order to better remove toxins levels in patients with ESRD, prolong the survival time of patients with ESRD.traditional Chinese medicine colon dialysis treatment to promote the removal of toxins, prolong the time of patients to enter the hemodialysis treatment, there is a high clinical value. And hemodialysis as the current conventional means of renal replacement therapy, its role is beyond doubt.