| Objective To evaluate functional MRI with graphy theoretical analysis in observing the changes of brain function in congenital deaf.Methods We acquired 18 bilateral congenital deaf and 11 healthy controls. All of them were subject to GE 3.0T Discovery 750 MR scan. Graphy theoretical analysis were applied to construct the brain functional networks. Two-sample test was performed to investigate group difference in brain functional networks between bilateral congenital deaf and healthy controls.Results Y=Cp/Cprand> 1, k= Lp/Lprand-l, o=y/k>l, two groups exhibited small-world architecture. Bilateral congenital deaf patients showed small-world architecture in brain networks under threshold. Compared with healthy controls, Bilateral congenital deaf patients showed significant increase in Cp, including brain regions of left caudate nucleus, left temporal pole:superior temporal gyrus, Eloc, including brain regions of left dorsolateral superior frontal gyms, right opercular inferior frontal gyrus, right triangular inferior frontal gyrus, bilateral rolandic operculum, right hippocampus, right parahippocampal gyrus, left superior parietal gyrus, right supramarginal gyrus, left angular gyrus, bilateral lenticular nucleus, left heschl gyrus and right inferior temporal gyrus; Eglo, including brain regions of right rolandic operculum, left supplementary moto area, bilateral insula, right heschl gyrus, right parahippocampal gyrus, right postcentral gyrus, bilateral supramarginal gyrus and right angular gyrus, and X. Moreover, Bilateral congenital deaf patients showed significant decrease in Lp, including brain regions of left angular gyrus, right supramarginal gyrus and angular gyrus, y and o.Conclusion Bilateral congenital deaf patients showed small-world architecture in brain networks under threshold. However, part parameters of small-world architecture had changed. The changes of multiple brain regions indicting that the reorganization had occurred in bilateral congenital deaf patients. |
PDF Full Text Request