| Background/Aims:The infection of chronic hepatitis B virus can lead the liver developing from chronic hepatitis to liver fibrosis, compensated cirrhosis, decompensated cirrhosis and liver failure. Many researches used liver biopsy or transient elastography to assess the effects of antiviral therapy found that long-term anti-HBV therapy may improve or reverse liver histological lesions. In this study, radionuclide angiography was applied to evaluate the development of chronic hepatitis B quantitatively. Besides, this research evaluates the correlation between radionuclide angiography and blood routine, liver function, liver fibrosis markers, and analyses the differences of radionuclide angiography between chronic hepatitis B patients and compensated hepatitis B cirrhosis patients, as well as the variations after taking nucleoside analogues (NAs), in order to provide a more simple and reliable method to estimate the condition of cirrhosis patients in clinical medicine.Methods:The clinical data of 68 cases of chronic hepatitis B were collected from August 2012 to January 2016, the First Affiliated Hospital, Zhejiang University. All the patients underwent radionuclide angiography.51 cases were male,17 cases were female, the average age was 44.29±11.11. Among them 33 cases were chronic hepatitis B,35 cases were compensated hepatitis B cirrhosis. The follow-up 20 cases who took NAs underwent radionuclide angiography again after 6-24 months (9 cases with chronic hepatitis B,11 cases with compensated hepatitis B cirrhosis). Each patient was collected corresponding medical record datas(when start taking NAs, ascites, esophageal pile, hepatic encephalopathy), HBV markers, blood routine, liver function, liver fibrosis markers, ultrasonography or CT and radionuclide angiography. SPSS 17.0 for windows were applied to analyze data. The measurement data of normal distribution was expressed as Mean±standard deviation (x±S), Non-normal distribution was expressed as median (range interquartile). Normal distribution between two samples were compared with t-test. Correlation analysis of normal distribution and non-normal distribution was employed with Pearson and Spearman analysis, respectively. Correlation between radionuclide angiography and age, blood routine, liver function, liver fibrosis markers was used multiplelinear regression analysis. All the statistical results was affirmed to have statistical significance when P < 0.05.Result:1.The correlation coefficients between HPI and CHE、ALB、TBIL, were 0.447 (P<0.001),0.25 (P=0.034),-0.339 (P=0.005) respectively.2.In Multiple Linear Regression Analysis, HPI and HAI were in relationship with Age, WBC, RBC, PLT, ALT, AST, GGT, CHE, TBA,TBIL, ALB,LN, HA, PIIIN-P and CIV. The largest influence is PIIIN-P, and the secondary is ALT.3.The differences of HPI and HAI between chronic hepatitis B patients and compensated liver cirrhosis in patients with chronic hepatitis B were examined by the independent two-sample t test, P<0.05. The HPI of compensated liver cirrhosis in patients with chronic hepatitis B (46.49±20.83) was lower than chronic hepatitis B (67.21±9.55), and the HAI was in contrary.4.The differences before and after taking NAs of HPI and HAI among 20 followed-up patients were examined by paired t-test(P>0.05). HPI and HAI of compensated liver cirrhosis in patients with chronic hepatitis B both showed significant difference after taking NAs(P<0.05).Conclusion:Radionuclide angiography could be well applied to evaluate the development of chronic hepatitis B and effects of nucleoside analogues’s therapy, especially for assessment of liver cirrhosis quantitatively and overall, as well as the reversal of cirrhosis after antiviral therapy. Combining with results of liver function, liver fibrosis markers, blood routine and age, it can be used to assess the disease together. After treatments of nucleoside analogues, the course of chronic hepatitis B could be controlled and fibrosis of liver in patients with cirrhosis can be improved. In summary, radionuclide angiography as a noninvasive, economical and convenient inspection means can evaluate the progress of disease and provide guides for clinical medication. |
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