An ERPs Study On Emotional Information Memory Bias Of Clinical Depression And Primary Insomnia

Objectives:Through analyzing the characteristics of the event related potential(ERP)in the study-recognition task to explore the cognitive characteristics in memory preference of the clinical depressions and the primary insomnia patients for different valence facial affective pictures.Methods:This research is divided into two experiments: experiment one was the differences between ERP of depression group and normal control group; Experiment two was the differences between ERP of insomnia group and normal control group. Selected 21 patients with depression and 23 patients with insomnia who are in accordance with international psychiatric diagnosis and classification standard of the tenth edition(ICD-10).Selected 21 cases of normal control group and 23 cases of normal control group who were matched with the depression group and insomnia group in the gender,age and education. Select the Chinese facial affective pictures of positive, negative and neutral(established by psychological research institutes in Chinese academy of sciences)as stimulus materials. Use classic learning-recognition task for the research object to collect the behavior and EEG data of the ERP.Results:1. The differences of ERP in the depression group and normal control group1.1 Behaviour outcomes:In different judgments of the different valence pictures, the average reaction time of the depression group was long than the normal group(p<0.05).It was not observed that the average reaction time had the statistical difference in the different valence pictures of the depression group or the normal group(p>0.05).The accuracy of the depression group was lower than the normal group(p<0.05).In the depression group, the accuracy of negative pictures was higher than positive and neutrals(p<0.05),but positive and neutral pictures had no statistical difference(p>0.05).In the normal group, no statistical difference was observed in accuracy of positive, negative and neutral pictures(p>0.05).1.2 EEG outcomes: In the early time windows(200ms-400ms),depression group was higher than normal group in the negative recognition pictures average amplitude of parietal region.In the late time windows(400ms-600 ms,600ms- 800ms),normal group was higher than depression group in the positive new pictures average amplitude of frontal area. In all time windows, it was not found that average amplitude had statistical difference in positive, neutral and negative pictures of the depression group or the normal group.2. The differences of ERP in the insomnia group and normal control group2.1 Behaviour outcomes: In different judgments of the different valence pictures,the average reaction time of the insomnia group was longer than the normal group(p<0.05).It was not observed that the average reaction time had the statistical difference in the different valence pictures of the insomnia group or the normal group(p>0.05).The accuracy of the insomnia group was lower than the normal group(p<0.05).In the insomnia group, the accuracy of negative pictures was higher than positives and neutrals(p<0.05),positive pictures were higher than neutral pictures(p>0.05).In the normal group, no statistical difference was observed in accuracy of positive, negative and neutral pictures(p>0.05).2.2 EEG outcomes: In the early time windows(200ms-400ms),insomnia group was higher than normal group in the different judgments of the different valence pictures average amplitude of frontal area or parietal region.In the late time windows(400ms-600 ms,600ms-800ms),normal group was higher than insomnia group in the all recognition pictures average amplitude of parietal region.In all time windows, it was all not found that average amplitude had statistical difference in positive, neutral and negative pictures of the insomnia group or the normal group.Conclusions:1.The abilities of cognitive processing,behavioral response and memory may be decreased in depressions.In depressions.There may be a negative information memory preference in depressions.In an other word,depressions may have a negative emotion congruent memory.2.200ms-400 ms time window may be a sensitive indicator for the negative recognition information processing of parietal region in depressions.400ms-600 ms, 600ms-800 ms time windows may be the sensitive indicators for the positive new information processing of frontal area.In all time windows, it was not found the processing preferences for different emotional valence information in depressions or normal people.3.The abilities of cognitive processing, behavioral responses and memory may be decreased in insomnia patients.There may be a negative information memory preference in insomnia patients.In an other word,insomnia patients may have a negative emotion congruent memory.4.It may be decreased in insomnia patients for the early cognitive processing function of frontal area or parietal region and the late recognition processing function of parietal region.Also,200ms-400 ms time window may be a sensitive indicator for the early cognitive processing function of frontal area or parietal region.What is more,400ms-600 ms and 600ms-800 ms time windows may be the sensitive indicators for the late recognition processing function of parietal region.In all time windows, it was not found the processing preferences for different emotional valence information in insomnia patients or normal people.