| Objectives:To construct a new type of closed extracorporeal circulation system and evaluate its safety and efficacy. Methods:There were 16 patients recuited receiving coronary artery bypass grafting assisted by cardiopulmonary bypass. Patients were randomized into two groups:the closed extracorporeal circulation system group (n=8) and the conventional extracorporeal circulation system group (n=8). Data including patients’general information, routine blood test and hematological biochemical index were separately recorded. Arterial blood samples were collected respectively before operation (TO),30min after the beginning of CPB (T1), 15min after aortic opening (T2),4 hours after operation (T3) and 24 hours after operation (T4). Arterial blood gas was detected at T1 and T2 time points; Blood samples at all time points were tested for free hemoglobin,interleukin-6, plasma prothrombin fragment-2, plasmin-antiplasmin complex and platelet factor -4.results:Among all the patients recruited, there occurred no accidents during the CPB. Arterial blood gas results showed that the oxygen and carbon dioxide partial pressure levels of the two groups were within the normal range, and there existed no statistical significant difference. The perioperative hemoglobin, white blood cell, platelet count, alanine aminotransferase, urea nitrogen and creatinine levels also showed no significant difference between the two groups. The variance analysis of free hemoglobin was tested by repeated measurement, F=1.513, P=0.239, thus no statistical difference existed between the two groups. The test of inflammatory factor also showed no difference. Conclusions:a new type of closed extracorporeal circulation system with good efficacy and safety has been successfully established. |
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