The Clinical Observation Of XiaoYao Pill Combined With Cytokine-induced Killer Cell In Treating HBeAg-positive Chronic Hepatitis B Patients With Syndrome Of Stagnation Of Liver Qi With Deficiency Of Spleen

Purpose:To study the efficacy and safety of Xiao Yao Pill combined with Cytokine-induced Killer cell in treating HBeAg-positive chronic hepatitis B patients with Syndrome of stagnation of liver qi with deficiency of spleen.Method:The 40 cases of HBeAg-positive chronic hepatitis B patients who included in the standard were divided into the control group and treatment group 20 cases each. The control group were treated with Cytokine-induced Killer cell for 20 days only, while the treatment group were given Cytokine-induced Killer cell for 20 days combined with Xiao Yao Pill 8 pill po tid for 12 weeks. Two groups of patients were compared with the liver biochemical index, HBV Mark, HBV DNA and the Traditional Chinese Medicine(TCM) symptoms and manifestations at baseline,4 weeks and 12 weeks, and for statistical analysis.Results:1. Biochemical response:After 4 weeks, the ALT normalization rate of the treatment group was 58.8% while the control group was 47.4%, there was no difference between the two groups(P>0.05). After 12 weeks, the ALT normalization rate of the treatment group was 88.2% which is higher than the control group 57.9%, and have significant difference (P <0.05).2. Virological response:After 12 weeks, the complete response patients of the treatment group were 6, partical response patients were 11, non-response patients were 3, the control group were 4,10 and 6, there was no difference between the two groups(P>0.05). The whole response rate of the treatment group was 85% and the control group was 70%, there also had no difference between the two groups(P>0.05).3. Serological response:After 12 weeks, the turning negative rate of HBeAg in the treatment group was 30%, not higher than that in the control group which was 25%(P>0.05).4. TCM symptoms and manifestations:After 12 weeks the syndrome integration of the treatment group was 3.45±1.76, lower than that of control group which was 10.80±5.588(P>0.05).Conclusion:XiaoYao Pill combined with Cytokine-induced Killer cell is an effective and safe therapy to HBeAg-positive chronic hepatitis B patients. It can significantly improve the TCM symptoms and the ALT normalization rate.