Effect Of Using Dexamethasone&Tropisetron On Postoperative Nausea And Vomiting In Patients With Segmental Mastectomy Under General Anesthesia

Purpose:To discuss Different effects by the use of different drugs during the perioperative:tropisetron or dexamethasone or tropisetron & dexamethasone and different time:before the end of surgery and before induction of anesthesia, after anesthesia induction, on the breast section excision effects of postoperative nausea and vomiting。To provide a theoretical basis for the prevention of postoperative nausea and vomiting drug intervention program.Method:The experiment was divided into two stages, the first stage:90 cases of patients with composite inclusion criteria. The patients were randomly divided into group I (DEX group) and group II (tropane group), group III (DEX & granisetron group) 3 group. After induction of anesthesia, the patients were treated with dexamethasone, tropisetron or dexamethasone & granisetron. The number of PONV after operation was observed and recorded in 24h. Statistical analysis of the experimental data, to find the best intervention drugs. In the second stage,60 cases of patients with complex inclusion criteria were selected. The patients were randomly divided into IV group (pre anesthesia treat group, n=30), V group (end surgery treat group, n=30). The best intervention drugs were given before the induction of anesthesia and the end of operation. The first stage of the experiment was to observe and record the number of PONV in patients with 24h after operation. Two groups of data and the first phase of anesthesia induction to give the best intervention of the drug group of statistical analysis, draw the conclusion.Result:1, the first phase of the three groups of patients, group III (Department of dexamethasone alkyl Gato Joan group) postoperative nausea and vomiting grade (WHO criteria), and postoperative nausea and vomiting in the VAS score were lower than in group I and group II, the difference is significant (P<0.05), ondansetron and dexamethasone Gato alkyl as the second phase dosing regimens, III group and the second phases in each group were compared.2, the first phase of the I group of postoperative nausea and vomiting (WHO standard), and postoperative nausea and vomiting VAS score slightly lower than the II group, but not significant (P>0.05).3, Second stage Ⅳ group (preoperative administration group) postoperative nausea and vomiting (WHO standard), and postoperative nausea and vomiting VAS scores were lower than the Ⅲ group, Ⅴ group, the difference was significant (P<0.05).4, second extremes in the Ⅲ group, Ⅴ group of postoperative nausea and vomiting (WHO standard), and postoperative nausea and vomiting VAS score difference was not significant (P>0.05).Conclusion:1, compared with the single administration of dexamethasone or the comparison of the patients with the care of the patients, the effect of the combination of dexamethasone and dexamethasone on the prevention of nausea and vomiting after partial breast resection was better.2, The effect of the prevention of postoperative nausea and vomiting before anesthesia induction was better than that of the patients with breast block resection.