| Objective: Radiotherapy plays an important role in the treatment of gastric cancer. Because at least partial volume irradiation of the kidneys cannot be avoided with radiotherapy in gastric carcinoma. However, few clinical data about the toxic potential in the radiotherapy of gastric cancer are available. We investigated the effects of this approach on short-term renal function.Methods:From July 2014 to June 2015, 40 patients of gastric carcinoma were treated at the Second Affiliated Hospital of Soochow University. All the patients are treated by Intensity-modulated radiotherapy(IMRT). The plans of radiotherapy were analyzed. Renal function was assessed by the changes in creatinine and creatinine clearance during follow-up. Statistical analysis was done using SPSS22.0 software for paired t-test,independent t-test, and ANOVA analysis.Results: Right kidney Dmaxis lower than dose of CTV, while there is no statistically difference between the left kidney Dmax and dose of CTV. The average dose of left kidney is higher than the right’s, and the average dose of kidney’s two sides is quite lower than dose of target volume and TD5/5of kidney. Right kidney Dmax of 5-Beam IMRT case is lower than the one of 6-Beam IMRT. Among 21 patients who had follow-up data,albuminuria was not discovered on patients with 6-monthMedian follow-up period(range between 3-9 months), and there is no statistical difference between GFR(MDRD) before and after their radiotherapy.Conclusion: According to detailed follow-up data of 21 patients’ cases, it is found that there is no obvious prompt radioactivity renal injury using IMRT treatment of gastric carcinoma. It suggests that the kidneys were prevented from radiation induced damage by using IMRT. |
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