Serum Osteocalcin Levels In Women With Polycystic Ovary Syndrome

Objectives1. This research is to investigate the change of serum osteocalcin(OC) and under-carboxylated osteocalcin(uc OC) levels in polycystic ovary syndrome patients(PCOS).2.To explore the relationship of serum OC and uc OC levels to body mass index(BMI),fasting blood-glucose(FBG),fasting plasma insulin(FINS), sexogen levels as well as other factors in the subjects with PCOS.MethodsBased on standards of Rotterdam diagnostic criteria in 2003, we recruited 59 PCOS patients who were admitted to the Department of Endorcrinology of the Third Hospital Affiliated to Suzhou University between 2013 and 2015 as PCOS group, and 46 age- and BMI-matched healthy women as control group. After clinical examination, the fasting blood of PCOS group and control group were collected and the fasting levels of glucose, insulin, total testosterone(TT), estradiol(E2), progesterone(P), luteinizing hormone(LH), Follicle stimulating hormone(FSH), prolactin(PRL), triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C),serum OC and uc OC levels were analyzed. Separately to measure height, weight, systolic blood pressure(SBP), diastolic blood pressure(DBP), and calculate BMI. Insulin sensitivity and insulin secretion were estimated by homeostasis model assessment-insulin resistance(HOMA-IR).Results1. Serum OC was significantly lower in PCOS patients compared to control[(13.12 ± 6.20) vs.(17.09±4.54) ng/ml, P<0.05]. However, serum uc OC was significantly higher in PCOS patients compared to control[(0.443±0.096) vs.(0.404±0.097) ng/ml, P<0.05].2. Serum OC was negatively correlated with BMI(r =-0.293, P <0.05), FINS(r =-0.322, P <0.01)and HOMA-IR(r =-0.325, P <0.01). There was a significantly positive correlation between serum OC and LH(r = 0.229, P <0.01). Serum uc OC was positively correlated with TT(r = 0.435, P <0.01)and LH(r = 0.281, P <0.05).3. Regression analysis showed that HOMA-IR was the independent risk factor of serum OC(β =-0.784, P<0.05). TT was the independent risk factor of serum uc OC(β = 0.435, P<0.05).Conclusions1. Decreases of serum OC levels have close relations with the obesity and insulin resistance in PCOS.2. Elevated of serum uc OC levels have close relations with the hyperandrogenism in PCOS, but have no relations with the insulin resistance.3. OC and uc OC may be involved in endocrinologic and metabolic regulation in PCOS patients. The pathophysiological mechanisms and moreover the possible clinical implications require further investigation.