Complications And False Negative Factorsin Ultrasound-Guided Percutaneous Peripheral Pulmonary Masses Biopsy

Objective:To evaluate the influencing factors of the complications and the false negative effect caused by ultrasound guided percutaneous lung biopsy, and to explore the methods to reduce the complication and false negative rate of percutaneous pulmonary biopsy.Methods:Theincidence and extend of postoperative complications were analyzed among a total of 451 ultrasound-guided percutaneous peripheral pulmonary masses biopsy cases. The pathological findings of ultrasound-guided percutaneous biopsy were compared with other methods (bronchoscopybiopsy, pleural fluid cytology, pathology, or surgery) or final clinical diagnosis to analyze the false negative rate of percutaneouspulmonary biopsy. The factors such as gender, lesion size, number of needle, body position and blood flow distribution were analyzed to discuss the influence of the complications occurrence and the false negative rate of percutaneous peripheral pulmonary masses biopsy.Results:In this study, the biopsy successful rate was 97.34% (439/451). A total of 180 cases were diagnosed malignantand 208 cases were diagnosed benign by pathological results. The diagnosis rate was 86.03%(388/451). There was3.55%descriptive diagnosis(16/451) and the false negative rate was8.27%(35/423). The complication occurrencerate was 12.20%(55/451). Whether there were abundant blood vessels or bronchial sign and the number of needle insertion were the main influence factors of the complication occurrence. Among various factors, lesion size significantly affected the false negative rate (P<0.05). For lesions bigger than 2cm, the larger the size, the higher the false-negative rate was discovered.Conclusion:1.The distribution of blood flows within the lesion, bronchial symptoms, number of needle insertion and the patients underlying disease are the main factors leading to the occurrence of puncture complications. CDFI assessment of lesion blood flow before biopsy and avoiding the blood flow during puncturing can reduce the incidence of pulmonary hemorrhage complications.2. Larger peripheral pulmonary lesions, the inflammatory formation around the lesions orbronchial pneumonia obstruction will increase there moving of the pathological tissue.