| ObjectivesRetrospectively analysis the clinical-pathologic proot and treatment to correlation of prognosis of fuzhengxiaoji method intervention in postoperative patients with triple-negative breast cancer, to find the factors of influence prognosis of triple-negative breast cancer.MethodsThis study collected the cases of postoperative patients with triple-negative breast cancer accepting fuzhengxiaoji method in Foshan Hospital of TCM outpatient and inpatient from January 2005 to January 2015, which were filled in survival data collection form, including age, menopausal status, tumor size, number of lymph node metastasis, tumor stage, fuzhengxiaoji method intervention time and other 17 possible factors. The time of diagnosis, specific time of Fuzhengxiaoji method intervention in and recurrence/death/time of last follow-up were recorded. Then a database was established, the survival rate calculated using life table, and the multivariate analysis of these individual performed by Kaplan-Meier method and Cox regression univariate, finally finded the independent factors affecting the prognosis TNBC.Results1.80 cases were evaluable, the whole group 1,2,3,4,5-year disease-free survival rate was 61%,54%,47%,40%,35%, with a median disease-free survival was 40 months; the whole group 1,2,3,4,5-year overall survival rate was 95%, 91%,81%,70%,65%, with a median overall survival was 115 months.2. On univariate analysis of disease-free survival (DFS) for triple-negative breast cancer patients:menstrual status, PS score, tumor size, histological grade, number of lymph node metastasis, tumor stage, TCM syndrome, type of surgery, fuzhengxiaoji method intervention time breast Cancer DFS affecting DFS (P＜0.05). Multivariate analysis showed:tumor size, histological grade, number of lymph node metastasis, type of surgery and fuzhengxiaoji method intervention time were the independent prognostic factors affecting DFS (P＜0.05).3. On univariate analysis of overal survival (OS) for triple-negative breast cancer patients:menopausal status, consolidation important diseases, tumor size, tumor stage, TCM syndrome and fuzhengxiaoji method intervention time affecting the OS (P<0.05). Multivariate analysis showed that:menopausal status, consolidation important diseases, tumor stage and fuzhengxiaoji method intervention time were the independent prognostic factors affecting OS (P＜0.05).4. Fuzhengxiaoji method intervention time＞24 months compared with 3-12 months＜3 months, can significantly prolong DFS in the whole group of patients (P＜0.05). Fuzhengxiaoji method intervention time>24 months compared with 12 to 24 months,3-12 months,＜3 months, can significantly prolong the whole group of patients with OS (P<0.05).Conclusion1. The independent prognostic factors of DFS of triple-negative breast cancer patients were tumor size, histological grade, number of lymph node metastasis, type of surgery, as well as fuzhengxiaoji method intervention time.2. The independent prognostic factors of OS of triple-negative breast cancer patients wer menopausal status, consolidation important diseases, tumor stage, fuzhengxiaoji method intervention time.3. The longer Fuzhengxiaoji method intervention time, the more benefits in DFS and OS triple-negative breast cancer patients will get. |
