| Objective:The studies have confirmed that herpesviruses were related to the incidence and severity of aggressive periodontitis. But owing to the difference of study population, sampling and detection method, it remains controversial. The present meta-analysis was aiming at identifying the association between herpesviruses and aggressive periodontitis by summarizing available case-control studies.Methods:We identified eligible case-control studies from PubMed, EMBASE, CNKI, WanFang and VIP up to October 1,2015. According to Cochrane Systematic Review, two reviewers screened literature independently and extracted data in accordance with the inclusion criterion. We accomplished synthesis and processing of data by using Revman and STATA software.Results:Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for quantitative synthesis. Fixed-or random-effects model was determined based on heterogeneity testing. The stability was investigated by sensitivity analysis. Publication bias was investigated by Begg’s rank correlation test and Egger’s funnel plot. Epstein-Barr virus (EBV) was significantly associated with aggressive periodontitis comparing with periodontally healthy group (10 studies:p=0.001, OR= 5.43,95% CI= 1.94-15.22). Although sensitivity analyses indicated this result was robust, publication bias for EBV was considerable. Human cytomegalovirus (HCMV) and Herpes simplex virus (HSV-1) had significant association with aggressive periodontitis (13 studies for HCMV:p<0.0001, OR= 5.37,95% CI= 2.35-12.26; 4 studies for HSV-1:p<0.001, OR=20.99,95% CI=8.52-51.73). Similar results were also found in the sensitivity analyses. No significant publication bias was observed. The association between HSV-2 and aggressive periodontitis was still inconclusive (2 studies:p=0.16, OR=3.80,95% CI=0.59-25.26).Conclusion:This meta-analysis suggests that HCMV and HSV-1 are significantly associated with aggressive periodontitis. |
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