Preliminary Study Of The Elastography Quantitative Analysis Of Tissue Diffusion In Diagnosis Of Hashimoto Thyroiditis

Objective:To explore the diagnostic performance of relative mean value (MEAN) and the blue area%(AREA%)of tissue diffusion quantitative analysis technology for Hashimoto thyroiditis (HT).Methods:From March 2014 to December 2015,54 patients(containing 51 women and 3 men),108 lesions, enrolled in our hospital who were diagnosed Hashimoto’s thyroiditis by clinical manifestation、physical examination and serological examination. According to the thyroid function’s laboratory test results,all 108 lesions are divided into three terms:HT euthyroidism group、HT subclinical hypothyroidism group、HT clinical hypothyroidism group. Fifty healthy participants(100 normal thyroid tissues) with normal thyroid function were enrolled as control group. All 108 lesions were examined by tissue diffusion quantitative technology.MEAN and AREA% were measured in the area the interested thyroid gland. Comparing respectively MEAN and AREA% differences between patient group and control group, analyze their relevances to the course of HT thyroid function. Built The ROC curve about MEAN and AREA% respectively in the diagnosis of Hashimoto’s thyroiditis and calculate respectively Youden index(Sensitivity+Specific-1) and calculate the area of the ROC curve. For about the highest diagnostic cut-off value and calculate the sensitivity and specificity of diagnosis cut-off value.Results:Using SPSS21.0 statistical software for statistical analysis, disease group’s MEAN value is 68.84±18.41,AREA% is(62.58±16.32)%;control group’s MEAN value is 121.58±20.86, AREA% is (19.67±7.37)%. The differences are statistically significant(P<0.05). HT euthyroidism group.HT subclinical hypothyroidism group and HT clinical hypothyroidism group’s MEAN value respectively is(89.92±6.47), (70.25±5.23),(44.56±10.03),AREA% respectively is (43.84±5.25)%, (59.87±6.05)%、 (81.81±6.96)%.The differences of MEAN and AREA% of each group are statistically significant(P<0.05).The correlation coefficient is -0.906 [r=-0.906(P<0.001)] between MEAN and the course of HT. The correlation coefficient is 0.924 [r= 0.924(P<0.001)]between MEAN and the course of HT. MEAN and AREA% built The ROC curve respectively in the diagnosis of Hashimoto’s thyroiditis. The AUC of MEAN is 0.940,the diagnostic cut-off value of MEAN is 87.5,the sensitivity of MEAN is 94.1% and the specificity of MEAN is 84.1%. The AUC of AREA% is 0.919,the diagnostic cut-off value of AREA% is 48.52%,the sensitivity of AREA% is 83.5% and the specificity of AREA% is 91.0%.Conclusion:Thyroid tissue stiffness differences are obvious between patients’ with Hashimoto’s thyroiditis and healthy participants’. Elasticity imaging diffusion quantitative analysis technology is more sensitive to find the differences, and noninvasive, and quantitative evaluation. The results of this study show that tissue diffusion quantitative analysis of the characteristic value of MEAN and AREA% is a new objective index for diagnosing of Hashimoto’s thyroiditis. The application of this technique can help to improve the accuracy of diagnosis of Hashimoto’s thyroiditis. Organization dispersion quantitative analysis is having some missed diagnosing and misdiagnosis.In practical application, it need to be combined with conventional ultrasound and comprehensive analysis.