The Clinical Research On Effect Of Pain Of Moderate To Severe Knee Osteoarthritis With Layers Adjusting External Application Therapy

Background:As the aging tendency of population grows, the morbidity of Knee Osteoarthritis(KOA) is also ascending year by year. The disease may seriously impact the daily life of the aged patients. The joint pain is the major complaint of KOA pati-ents, thus controlling the pain should be the crucial part of treating KOA.Purpose:Comparing the treatment outcomes of Layers Adjusting External Application(LAEA) and the Diclofenac Diethylamine Emulgel, objectively evaluate and analysis the clinical effects of treating the patients who are indicated for knee arthroplasty, explore the pain character of severe KOA patients and the clinical effects of LAEA alleviating the knee joint pain.Methods:32 patients were accordance with the inclusion criteria. They were randomly divided into treatment group(LAEA group) and the control group,16 in each, respectively. Patients received treatments for 3 weeks. Compare the WOMAC score, NPQ pain score, the improvement of joint function, evaluate the clinical effects of alleviating the knee joint pain in four different time nodes:1d post-therapy,21d post-therapy,2month post-therapy and 3month post-therapy.Results:1, there were no significance between the two groups in the comparison of gender, age or left-right side (P>0.05).2, During the initial diagnosis, there were no significance between the two groups in the comparison of walking, climbing stairs, sleeping at night, sitting,lying, standing, total WOMAC score, WOMAC pain score or NPQ pain score (P>0.05). There were significance between the comparison of 21 d post-therapy,2month post-therapy, 3month post-therapy and the initial diagnosis (P<0.05). The two kinds of drugs have good control effect on the pain of moderate and severe KOA patients.3,In the comparison of the voltaren group and LAEA group, there were significance in the comparison of walking, climbing stairs, sleeping at night, sitting,lying, standing, total WOMAC score, WOMAC pain score in 7d post-therapy (P<0.05). In the voltaren group, there were no significance in the comparison of WOMAC pain score in 14d post-therapy and 21 d post-therapy (P>0.05), whereas there were significance in the LAEA group,too. (P<0.05). That Votalin on KOA control of pain onset time is easy to short sticking layer.The onset time of voltaren group is shorter than LAEA group.4,In the LAEA group, there were no significance in the comparison of climbing stairs, standing, total WOMAC score, WOMAC pain score in 2month post-therapy and 3month post-therapy (P>0.05), whereas there were significance in the control group (P<0.05). The recurrence rate of Votalin group is higher after the withdrawal that drug.5,As the NPQ score were both more than zero in the initial diagnosis, both groups can be diagnosed as neuropathic pain. There were significance between the 21 d post-therapy and 2month post-therapy,3month post-therapy in the NPQ score, however the LAEA group presented continuously declination, and the control group raised continuously.6, There were no significance in the improvement of joint function in initial diagnosis,21d post-therapy and 2month post-therapy, there was significance in 3month post-therapy (P<0.05).7, The effective rate of both groups were 100%. The efficiency rate of LAEA group was 50%, significantly higher than control group which showed a efficiency rate of 12.5%(P<0.05)Conclusion:The joint pain of severe KOA patients may be the pathological pain. LAEA and the Diclofenac are both effective in the improvement of severe KOA patients joint pain and life quality. Nevertheless, LAEA shows significant advantage in the aspect of long-term pain control and improvement of knee joint functions.