| Objection:Many studies focused on finding some serum biomarkers for predicting the prognosis of cancers, which had achieved success. Alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) are currently considered to be effective prognostic factors of osteosarcoma, but the results are inconsistent among the studies. C-reactive protein (CRP), uric acid (UA), neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) have been proposed to predict clinical outcomes in many types of cancers. However, their influences on the prognosis of osteosarcoma patient are lack of evidence.Methods:A retrospective cohort study of 125 patients was performed to assess the prognostic significance of serum biomarkers in osteosarcoma. Receiver operator characteristics(ROC) curves were performed to analyzed the diagnostic role of the serum biomarkers for metastasis. The cut-off points of the serum biomarkers were determined based on the sensitivity and specificity levels derived from Area Under ROC (AUC) curves. The relationship between serum biomarkers and efinicopathological factors such as age, sex, metastasis, tumor site, pathologic type, and pathological fracture were analyzed. Kaplan-Meier survival analysis were used to assess the impact of serum biomarkers on the overall survival in patients with osteosarcoma.Results:Our results showed that high LDH, ALP, NLR, LMR, PLR and low AGR, ALB were significantly associated with metastasis at diagnosis. High LDH, ALP, FIB and low ALB were associated with shorter overall survival.Conclusion:High LDH, ALP, FIB and low ALB levels were associated with shorter overall survival, they might be effective prognostic factor of osteosarcoma. High NLR, LMR, PLR and low AGR had significant relationship with progression and metastasis of osteosarcoma, but failed to be prognostic factor in the early phase. No significant relationship was found between COP-NLR and osteosarcoma progress or prognosis. |
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