Study On Preparation Of Ordered Macroprous Molucelarly Imprinted Polymers And Their Applications In Drug Separation

The ingredient of traditional Chinese medicine is complex, Exploiting the materials with high adsorption selectivity and excellent mass transfer kinetics is the key research areas in separation science.The molecularly imprinted polymer(MIP) is a kind of separation materials that has the specific recognization ability to the aimed molecular, It has attracted people much attention, and has potential industrial application in separation and enrichment of the effective ingredient of traditional Chinese medicine. However, MIP has some drawbacks,such as,the complexity of the following disposing and slow rebinding combing. And three-dimensionally ordered macroporous MIP(3DOMMIP) with high porosity and homogeneous macroporous channels can improve the adsorption rate and adsorption performance. Predictably,3DOMMIP will have a promising application prospect in the drug separation.The first part:we prepared the monodisperse SiO2 microspheres using the StOber method.And the particle size is about 298nm.Then,we assembled them into colloidal crystal template by centrifugation. SEM observation shows that microspheres aligne orderly with an fcc structure.The second part:Cinchonine 3DOMMIP was prepared by a combination of the colloidal crystal templating method and molecular imprinting technique. We used cinchonine as template molecular, methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinker and chloroform as solvent, SiO2 as colloidal crystal template to prepare 3DOMMIP, MIP was simultaneously synthesized with the same recipe as 3DOMMEP. SEM and BET measurements show that 3DOMMIP has more regular macroporous structure, narrower macropore distribution, higher surface area and porosity compared with MIP. The isothermal and kinetic data of both polymers can be fitted with Freundilich model and pseduo-second order equation, respectively. Their specificities to the template molecules are also similar. However, the binding capability, adsorption rate coefficient and internal effective diffusion coefficient of the 3DOMMIP are higher than MIP when the particle size is above 54 μm.The third part:We used quercetin as template molecular, methacrylic as functional monomer, ethylene glycol dimethacrylate as crosslinker and tetrahydrofuran as solvent, SiO2 as colloidal crystal template to prepare 3DOMMIP. MIP was simultaneously synthesized with the same recipe as 3DOMMIP. Experiment results shows that 3DOMMIP has a more regular macroporous structure and higher adsorption rate coefficient. Both polymers have the specific recognization to the template molecular;In the solid phase extraction(SPE) process, compared with MIP,3DOMMIP has higher loading amount and substracts are easy to be eluted.In this study, we used SiO2 as collidal crystal template,chinchonine and quercetin as template molecular,the preparation of 3DOMMIP were established by a combination of the crystal template method and molecular imprinting technique. Compared with MIP,3DOMMIP could improve the binding capability and adsorption rate coefficient.This could provide a new material for the drug separation.