The Study Of The Relationship Between Visceral Adiposity Index And Glucolipid Metabolic Disease

ObjectiveVAI (visceral adipose index) is a specificity index which can evaluate the functions of the visceral fat functions and the calculation of VAL contains BMI, WC, HDL, TG. There are several related researches about the prognosis of risk factors, such as VAI and early type 2 diabetes mellitus, fatty liver, coronary heart disease. However, on the one hand, each result is inconsistencies for different age, sex, race, and other factors; on the other hand, those researches not analyze the glucose and lipid metabolism. Accordingly, this study would investigate the correlation of VAI and glycolipid metabolic disease (GLMD), and calculate a cutoff point of VAI to GLMD, which provide reference for the early prevention and treatment of clinical glycolipid metabolic disease.Methods①1810 samples (777 males and 1033 females) are included, which come from the Department of Cardiovascular Medicine and Endocrinology, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine during 2013 to 2015; the Department of Traditional Chinese Medicine, First Affiliated Hospital of Guangdong Pharmaceutical University; recruited patients, metabolic diseases research center of integrative medicine clinical Department, Guangdong Province, ages 19-74. Among these samples, there are 1374 patients with glycolipid metabolic disease (GLMD),436 people without GLMD. Using the same method measured weight, height, waist circumference (WC), calculate BMI, waist-high ratio (WHtR).②According to the data of WC, VAI, BMI, WHtR value, the indicators of abnormal glucose metabolism refer to diagnostic criteria for pre-diabetes, diabetes, Dyslipidemia in the Guide to type 2 diabetes prevention (2013), and the indicators of dyslipidemia refer to The 2007 Chinese adult dyslipidemia prevention and treatment guide.③ Using SPSS19.0 analyzes statistics.(X±s) stands for normal distribution of measurement data, and a percentage (%) stands for count data. Normally distributed data using ANOVA analyze statistics and non-normally distributed data using non-parametric rank test, Spearman rank correlation and trend Chi-square test analyze statistics. When P<0.05, it means that exists statistical significance.Results① VAI, BMI have no correlation with abnormal glucose metabolism alone.② VAI is significantly correlated with the simple lipid metabolism disorders group.③ VAI is correlated with sugar and lipid metabolism in abnormal groups.④ VAI is correlated with glycolipid metabolic disease (GLMD).⑤ The VAI cutoff point of GLMD in male is 2.0; the females’cutoff point is 1.96; the young patients’cutoff pointis 2.06; the middle-aged is 2.0 and the old is 1.96.GonelusionWhen comprehensive analyzed the abnormal glucose metabolism, lipid metabolism and sugar combine lipid metabolism disorders, the correlation between VAI and GLMD is superior to BMI, WC and WHtR. It shows that VAI have predictive value for complex and comprehensive disease, and can also be used as indicators of GLMD’s early diagnosis, then determine the prognosis of the disease. As for the cutoff point of GLMD, VAI could be further verified in large samples and various region.