Analysis Of The Influence Of The Level Of Thyroid Hormone On The Prognosis Of Patients With Heart Transplantation

[Objective] In this retrospectively study, we compared perioperative and survival rate of heart transplant patients with different thyroid hormone patients.[Methods] From Sept 2009 to July 2014。the heart transplant center of Fuwai Hospital had completed a total of 270 cases, and the clinical data of all patients include thyroid hormone and follow-up information were analyzed. According to the level of TSH, patients were divided into three groups:<0.55,0.55-2.5,>2.5mIU/L. Also, according to the level of fT3, patients were divided into three groups:fT3≤2.36、2.37-2.79、 ≥2.80pg/ml. Perioperative recovery data and prognosis of three groups were compared.[Result] In this study,270 patients were enrolled, the average age was (44.58±13.30) years old, male 228(84.4%), female 42 (15.6%). The average follow-up time was(31.88±17.48) months, and the follow-up rate was 100%. The low T3 syndrome in 46 cases (17%) and subclinical hypothyroidism 56 cases (20.7%), clinical hypothyroidism in 11 cases (4.1%), the three accounted for 41.8%.The proportion of low thyroid hormone in patients with heart transplantation is much higher than the general population. Perioperative duration of ICU and mechanical ventilation duration had no statistically significant difference(P>0.05) within the three groups of different TSH. The TSH: 0.55-2.5mIU/L group had shorter ICU duration and mechanical ventilation duration, and The TSH>2.5mIU/L group had longest ICU duration and mechanical ventilation duration. In the long term, TSH>2.5 mIU/L, is an independent prognostic factor of death. Increased TSH were negatively related to a poorer prognosis in heart transplant. Perioperative duration of ICU and mechanical ventilation duration had no statistically significant difference(P>0.05) within the three groups of different fT3. Different fT3 groups had no statistically significant different in long term prognosis(P>0.05).[Conclusion]For patients with heart transplantation, TSH>2.5 mIU/L is an independent prognostic factor of death.