Effect Of Dietary And Exercise Intervention In Overweight And Obese Women With Polycystic Ovary Syndrome

Background:Polycystic ovary syndrome (PCOS) is a common condition with a range of clinical features that affects women of reproductive age. It is not only relate to reproductive system, alse can cause a variety of metabolic abnormalities. Overweight and obese patients with PCOS have more severe cardiovascular and metabolic risk factors than their lean counterparts. It has testified that dietary and exercise intervention can improve the disease status of overweight and obese with PCOS in other country, however, there is less related research in China. Thus, it is necessary to explore the effect of dietary and exercise intervention in overweight and obese women with PCOS.Objectives:To investigated the effect of dietary and exercise intervention on weight, BMI, waist circumference, waist-hip ration, fasting insulin, fasting plasma glucose, homeostasis model of insulin resistance, sex hormones, lipid levels.Methods:A quasi-expermental study was used. A convenient sample of 74 women with a BMI= 24kg/m2 from Peking Union Medical College Hospital was enrolled. They were divided into intervention group(N=37) or control group (N=37) according to the time sequence of seeing doctor. The intervention group was provide exercise, dietary counseling and detailed plans at every month at the hospital. In addition, each counseling session include a personalized feedback based on their 4-day-records. Follow-up phone calls and Wechat were conducted every week. The control group was just provided usual care. Data were collected at 4-16 weeks. Outcome measures were weight, BMI, waist circumference, waist-hip ration, fasting insulin, fasting plasma glucose, homeostasis model of insulin resistance, sex hormones, lipid levels.Results:66 women complete data collection procedures,34 women in intervention group and 32 women in control group. The weight, BMI, waist circumference, waist-hip ration, fasting insulin, fasting plasma glucose, homeostasis model of insulin resistance, luteinizing hormone, testosterone, total cholesterone, triglyceride, low density lipoprotein cholesterone were significant lower than control group (P<0.05). There were no statistically significant difference in LH/FSH, high density lipoprotein cholesterone.Conclusions:Dietary and exercise intervention can reduce the weight, BMI, waist circumference, waist-hip ration, fasting insulin, fasting plasma glucose, homeostasis model of insulin resistance, luteinizing hormone, testosterone, total cholesterone, triglyceride, low density lipoprotein cholesterone among overweight and obese women with PCOS. It is not associate with a significant positive effect on LH/FSH, high density lipoprotein cholesterone.