Visible Light-induced Trifluoromethyl Halogenated Reaction Of Olefins&Design And Synthesis Of Double G9a-HDAC Inhibitors

In recent years, the visible light catalytic reaction has attracted great interest in organic synthesis industry, mild reaction conditions, easy to handle, unlimited use and environmentally friendly, and therefore has a high prospect. This article focuses on the promotion by the visible light olefins functionalized reaction research and some drug content, including a total of two parts:The first part of the synthesis of trifluoromethyl halogen compound. The conditions is the white LED, the catalyst Mes-Acr+, additives TFA, nitrogen atmosphere, the solvent DCE,at room temperature, the reaction conditions, the title compounds have moderate yields.The second part is the synthesis of G9a-HDAC inhibitor compounds. According to currently available drugs of G9 a and HDAC inhibitor, and access to relevant literature, we design and synthesis of a number of double-inhibiting compound based amino pyridine quinazoline and the drug SAHA.