Predictive Value Of Late Gadolinium Enhancement By Cardiovascular Magnetic Resonance In Patients With Heart Failure

Objective To evaluate the prognosis of late gadolinium enhancement by cardiovascular magnetic resonance in patients with heart failure(HF).Methods 70 heart failure patients from September 2011 to February 2015 were enrolled in this study after undergoing CMR examination.According to the CMR,the patients were categorized into LGE(+) group and LGE(-) group.Baseline data,clinical characteristics,ejection fraction(EF) level in half a year and occurrence of adverse events during a 24-month mean follow-up were recorded. All the clinical data collected were compared.Sex,age,LGE,NYHA, left ventricular end diastolic diameter(LVEDD), Lg(NT-proBNP) and LVEF difference were taken into Cox proportional hazard model to analyze the predictor.Kaplan-Meier is used to compare the event-free survival of the two groups.Results A total of 45.7% of patients in LGE(+) group and LGE is more frequent in men. The Lg(NT-proBNP) level in LGE(+) group was significantly higher that in LGE(-) group[(3.48±0.43) :(3.24±0.47),p=0.03].Baseline characeristics,conventional drugs used were similar between the two groups.EF level in half a year increased significantly compared with previous EF level(p<0.05).In cox regression analysis,LGE was a strong predictor for adverse events(HR=5.663,p=0.001,95%CI:1.988 ~ 16.131);The 2-year incidence of adverse events was significantly higher in LGE(+) group[62.5%(20/32)] compared with LGE(-) group[15.8%(6/38),p<0.001].Conclusion A CMR LGE in HF patients is a strong predictor for adverse events.