Retrospective Analysis Of Infection In Patients With Systemic Lupus Erythematosus

Objectives:To explore the clinical features of infection in systemic lupus erythematosus and make sure the influence of these factors such as age,course of disease,hospital stay,damage system on patients,and to analyze the pathogens distribution and antibiotic sensitivity and resistance patterns;In order to provide theoretical basis for the prevention, early diagnosis, early treatment, rational selection of antibiotics, improving the prognosis and improving the survival rate of infection in systemic lupus erythematosus.Methods:Clinical data from 177 SLE patients were collected and all participants were divided into the infection (n= 88) and non-infection groups (n=89).The site of infection, type of pathogen, treatment method and other information in 88 SLE patients complicated with infection were retrospectively reviewed.The clinical features of 88 SLE patients complicated with infection were analyzed by SPSS 19.0 statistics soft-ware, using of x2 test,t test, rank-sum test.The risk factors of infection in SLE patients were assessed by logistic regression analysis.Results:1.There were 88 SLE patients complicated with infection (49.7%) of 177 patients.Rrespiratory tract (64.8%)and Urinary tract(19.3%),Skin mucous membrane(9.1%) were the common infection sites.The gram negative bacteria was the most common pathogens, the yeast was the common fungal, and the herpes zoster virus was the common virus.2.Univariate logistic regression analysis demonstrated that hospitalization time, SLEDAI score, CRP, serum albumin, complement C3, PDN daily dose, multi system damage were associated with the SLE complicated with infection.3.Multivariate logistic regression analysis revealed that hospitalization time, CRP and total daily dose of hormones were independent risk factors of SLE complicated with infection (P<0.05).4.The high drug resistance of gram negative bacteria were most of the broad-spectrum penicillins, first and second generation cephalosporins, aminoglycosides, sulfonamides, quinolones.The betantibiotic sensitivity of gram negative bacteria were ceftazidime, imipenem, Meropenem, cefoperazone/ sulbactam, piperacillin Westwood/tazo. The high drug resistance of Gram positive bacteria were penicillins, cephalosporins, quinolones and aminoglycoside.The antibiotic sensitivity of Gram positive bacteria were vancomycin, chloramphenicol, quinupristin/dalfopristin. Fungi had a good sensitivity to most antibiotics.Conclusions:Rrespiratory tract was the main part of infection in SLE and the major pathogen of infection in SLE was gram-negative bacteria. Multivariate logistic regression analysis revealed that hospitalization time, CRP and total daily dose of hormones were independent risk factors of SLE complicated with infection.The bacteria had a high resistance to most of the antibiotics.Taking prevention is the first measure of SLE complicated with infection in clinical work.Early diagnosis and treatment,rational use of antibiotics in clinic should be performed to improve clinical prognosis the survival rate.