The Study Of Resting State FMRI Changes In Cervical Dystonia Patients Based On Fractional Amplitude Of Low-Frequency

Objective:In order to understand the cerebral activation patterns of cervical dystonia(CD)and explore the pathogenesis and pathophysiological process of CD, application of resting state functional magnetic resonance imaging(Rs-fMRI) technology, to compare the difference of factional amplitude of low frequency fluctuation(fALFF) between patients with cervical dystonia(CD) and healthy controls in the rest.Methods:Collected from January 2013 to March2016 in our hospital clinic diagnosis of cervical dystonia patients, as well as the age、gender and education background matched healthy controls,21 cases in each group. First, improve the general information of patiens and use Tsui scale to assessment of patients severity score. Second, all of the patients were scanned with resting state fMRI (rs-fMRI) as soon as possible.Used the software DPARSF to preprocessed the image data. Using the two sample T test to compare patients with CD group and healthy control group differences in brain fALFF. By the SPSS17.0,we made the statistical analysis of the datas and research into the correlations of them.Results:Compared with the normal control group, there was a significantly increased fALFF in the left cerebellum and a significantly decreased fALFF in the left posterior cingulate cortex/precuneus, right posterior cingulate cortex/precuneus, left middle temporal gyrus, right angular gyrus, left postcentral gyrus, right supplementary motor area.Conclusion:There may be both an abnormal default mode network and cerebellum with cervical dystonia patients.The present study suggests that abnormal sensorimotor integration may play a role in the pathophysiology of CD.