Optimization Diagnostic Imaging Methods In Osteosarcoma For Clinical Intentions

Objective:To optimize osteosarcoma diagnostic imaging examination of DR, CT and MRI in providing diagnosis and clinical staging information by compare the detecting ability.Materials and Methods:A retrospective analysis was conducted in 134 cases of osteosarcoma that included complete clinical and imaging (DR, CT or MRI) information, in which 32 cases had all DR, CT and MRI information. All of 134 cases were confirmed by pathology. Three experienced radiologists in skeletal muscle groups were asked to read the films in double-blind separately and randomly. Bone destruction, tumor bone, periosteal reaction, periosteum triangle and soft tissue mass were listed as diagnostic information.The infiltration range and border of osteosarcoma were listed as clinical stages information. A few obey most as final result in defined, observed and record the diagnosis and staging information of osteosarcoma in different examination methods. Final result in different examination methods were statistical analyzed with SPSS. The detecting ability of osteosarcoma diagnosis and staging information from DR, CT and MRI would be calculated and compared. Optimize osteosarcoma diagnostic imaging examination would be summaried.Results1. The rate of detecting the diagnostic of osteosarcoma of three examination methods were not affected by sample size.2. The detecting rate of bone destruction, periosteal reaction and periosteum triangle by three methods had no significant statistical differences (p > 0.05).The detecing rate of tumor bone between MR and DR,CT had significant statistical differences (p< 0.05). Simple MRI couldn’t affirm bone tumor. The ability of DR to detect smaller tumor bone inferior to CT.The detecing rate of soft tissue mass between DR and CT,MR had significant statistical differences (p< 0.05).The detecting ability of Simple DR in soft tissue mass was the worst.3. The detecing rate of osteosarcoma diagnostic signs between Combined three methods and simple CT or any combination of the two methods had no significant statistical differences (p> 0.05). The detecing rate of tumor bone between Combined three methods and simple DR had significant statistical differences (p<0.05). The detecing rate of soft tissue mass between Combined three methods and simple MR had significant statistical differences (p< 0.05). Generally, simple CT or any combination of the two methods could reach to the detecting ability of Combined three methods in osteosarcoma diagnostic signs.The drawback of simple DR was the low detecting ability of soft tissue mass. The drawback of simple MRI was the low detecting ability of tumor bone.4. The statistical results of measuring maximum transverse diameter of the lesions shown that DR with the other three groups had significant statistical differences (p<0.05).There was no significant statistical differences between CT,T1WI and T2WI(p> 0.05). The results of measuring maximum transverse diameter of the lesions by DR lessed than CT and MRI.The measuring results had no significant differences between CT and MRI.The statistical results of measuring intramedullary vertical diameter of the lesions shown that respectively compared DR and CT with the other three groups has significant statistical differences (p< 0.05).There was no significant statistical differences between T1WI and T2WI(p>0.05).The measuring results of DR was minimum and MRI was maximum.5. The distribution of infiltration border of osteosarcoma by three methods had significant statistical differences (p<0.05).While after pairwise comparison, the population distribution between DR and CT,MRI had significant statistical differences (p< 0.05), between CT and MRI had no significant statistical differences (p> 0.05).The detecting ability of infiltration border of DR inferior to CT and MRI.The results had no significant differences between CT and MRI.Conclusion:1. The ability to detect bone destruction, periosteal reaction and periosteum triangle by three methods had no statistically significance. The ability of MRI to detect tumor bone inferior to DR and CT. The ability of DR to detect soft tissue mass inferior to CT and MRI.2. Single DR, CT or MRI, CT was the best examination in detecting the diagnostic signs of osteosarcoma comprehensively.3. MRI was the best examination methods in detecting the infiltration range and border of clinical staging information of osteosarcoma comprehensively.4. Combined DR,CT and MRI were the optimized imaging examination method to integrated supply of the information of diagnosis and clinical staging.