| Objective:This paper aimed to preliminarily explore the efficacy of Yiqi Gushen lithagogue formula combined with Tamsulosin for upper ureteral calculi with Qi deficiency of spleen and kidney following ESWL through a retrospective investigation.Methods:A retrospective investigation was adopted to investigate the patients who were admitted to the Guangdong Province Traditional Chinese Medical Hospital from September,2013 to December,2015 and underwent the ESWL. According to whether the patients took The Yiqi Gushen lithagogue formula after ESWL, the author divided the 106 upper ureteric calculi patients with dampness-heat syndrome combined with Qi deficiency of spleen and kidney into group A (Yiqi Gushen lithagogue formula+tamsulosin) with 61 patients and group B(tamsulosin) with 45 patients. In this paper, the researcher investigated the efficacy of lithagogue treatment with The Yiqi Gushen lithagogue formula through collecting the patients’general data and imaging data 2 weeks (± 3 days) and 4 weeks (±3 days) after ESWL, and whether they underwent surgeries and the formation of steinstrasse. In addition, SPSS17.0 was applied for a statistical analysis of the collected data. The normality test was performed on the measurement data, and if they were not normally distributed, the Mann-Whitney test would be used for comparisons. What’s more, the count data were compared through x2 test.Results:1. The general data between patients in two groups including age, gender, disease’s duration, preoperative urine count and stone sizes was not statistically significant(P＞0.05) while the TCM syndrome investigation indicated that, the differences in waist aches, fatigue, frequent micturition and urgent micturition, and loose stool did not have a statistical significance either(P＞0.05). All these results showed that the overall conditions of patients in two groups have a kind of comparability before the treatment.2. Comparison of calculus removal situation at 2 weeks (±3days) after ESWL between the two groups revealed that 10 (16.4%) patients were cured, 36(59.0%) patients showed effectiveness and 15 (24.6%) patients presented ineffectiveness in the group A; 4 (8.9%) patients were cured,31 (68.9%) patients displayed effectiveness and 10 (22.2%) patients demonstrated ineffectiveness in the group B, showing statistically significant differences (P＜0.05). Comparison of total effective rate suggested a total effective rate of 75.4%(n= 46) and 77.8%(n=35) and a total inefficiency of 24.6% (n=15) and 22.2%(n=10), respectively, in the group A and B, presenting no statistically significant differences (P＞0.05). Comparison of calculus removal showed complete removal in 10 (16.4%) and 4(8.9%) patients, and non-removal in 51 (83.6%) and 41 (91.1%) patients, respectively, in the group A and B, also demonstrating no statistically significant differences (P＞ 0.05).3. Comparison of calculus removal situation at 4 weeks (±3 days) after ESWL between the two groups revealed that 38 (62.3%) patients were cured,18 (29.5%) patients showed effectiveness and 5 (8.2%) patients presented ineffectiveness in the group A; 18 (40.0%) patients were cured,20 (44.4%) patients displayed effectiveness and 7 (15.6%) patients demonstrated ineffectiveness in the group B, showing statistically significant differences (P＜0.05). Comparison of total effective rate suggested a total effective rate of 91.8%(n=56) and 84.4%(n=38) and a total inefficiency of 8.2% (n=5) and 15.6%(n=7), respectively, in the group A and B, presenting no statistically significant differences (P＞0.05). Comparison of calculus removal showed complete removal in 38 (62.3%) and 18 (40.0%) patients, and non-removal in 23 (37.7%) and 27 (60.0%) patients, respectively, in the group A and B, demonstrating statistically significant differences (P＜0.05).4. A comparison in whether patients in the two groups underwent surgeries during the lithagogue process presented that 4 patients(6.6%) in group A and 6 patients(13.3%) in group B took surgeries as an alternative during the treatment, ant the difference was not statistically significant (P>0.05).5. Through investigating the formation of steinstrasse during the lithagogue process between the two groups, the researcher found that 1 patient (1.6%) in group A and 3 patients (6.8%) in group B were confronted with steinstrasse, and this difference was not statistically significant (P＞0.05).Conclusion:For patients with upper ureteral calculi with Qi deficiency of spleen and kidney, application of Yiqi Gushen lithagogue formula combined with Tamsulosin produced better calculus removing effect than did Tamsolosin alone. |
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