The Predictive Value Of Clinical Risk Factors And FVL And Prothrombin Gene Mutation Of Pulmonary Embolism

ObjectiveTo study the clinical risk factors of pulmonary embolism and investigate the occurence frequency of the coagulation factor V Leiden mutation and prothrombin G20210 A mutation(FII G20210A) in the patients with pulmonary thromboembolism(PTE) in northeast China. In order to clarify the predictive value for diagnosis of the two genetic mutation detection in PTE of the population in northeast China.MethodsAll 126 PE patients have clinical risk factors, including deep vein thrombosis(DVT) in 90 cases(71.4%); 41 cases cardiopulmonary diseases(32.5%), including 15 cases of COPD(11.9%), 11 cases of coronary heart disease(CHD)( 8.7%), 15 cases hypertension(1.9%); 30 cases surgery( 23.8%), including 3 cases joint replacement(2.4%); 25 cases tumor history(19.8%), including 4 cases lung cancer(3.2%); 21 cases trauma history(16.7%), including 3 cases traffic accident(2.38%); 10 cases(7.9%) bed-ridden; 9 cases obesity(7.5%); DVT thrombolysis treatment attack of 8 cases(6.3%); 1 case SLE( 0.8%); 1 case burn( 0.8%). Havingthe history of surgery and lower extremity venous thrombosis are 25cases(19.8%). There are 47 cases(37.3%) that having one risk factor, and45 cases(35.7%) that having two risk factors, 27 cases(21.4%) having three factors, for four or more risk factors are7 cases(5.6%). All Prothrombin genes have existed in 407 and 99 bp of DNA bands, all Factor V genes appear only on a 241 bp band. The mutation frequency of FVL and prothrombin G20210 A is 0%, so there was no statistically difference compared with the control group(P > 0.05). FVL and prothrombin G20210 A gene heterozygous or homozygous mutations were not found in the two groups.ResultsAll 126 PE patients have clinical risk factors, including deep vein thrombosis(DVT) in 90 cases, 71.4%; cardiopulmonary disease, 41 cases,32.5%,(15 cases of COPD, 11.9%; coronary heart disease(CHD) in 11 cases, 8.7%; hypertension 15 cases, 1.9%); surgery, 30 cases, 23.8%,(including joint replacement in 3 cases, 2.4%); tumor history, 25 cases,19.8%,( including 4 cases of lung cancer, 3.2%); trauma history, 21 cases,16.7%,(including 3 traffic accident cases, 2.38%); 10 cases(7.9%) of bed-ridden; obesity, 9 cases(7.5%); DVT thrombolysis treatment attack of 8 cases(6.3%); SLE, 1 case, 0.8%; burn in 1 case, 0.8%. Both having the history of surgery and lower extremity venous thrombosis are 25 cases,19.8%. There are 47 cases(37.3%) that having one risk factor, and 45cases(35.7%) that having two, 27 cases(21.4%) having three factors, for four or more risk factors are7 cases(5.6%). All Prothrombin genes have existed in 407 and 99 bp of DNA bands, all Factor V genes appear only on a 241 bp band. The mutation frequency of FVL and prothrombin G20210 A is 0%, so there was no statistically difference compared with the control group. FVL and prothrombin G20210 A gene heterozygous or homozygous mutations were not found in the two groups.Conclusion1、 The common clinical risk factors of pulmonary embolism includes deep vein thrombosis, cardiopulmonary disease surgery, trauma, tumor, bed-ridden, obesity and others.2、 FV Leiden mutation and prothrombin G20210 A mutation detection of the pulmonary thromboembolism diagnosis may have no predictive value for the crowd in northeast China.3、 Clinical risk factors is more important of predictive value for diagnosis of pulmonary embolism in our country, the people with clinical risk factors should be given early intervention to reduce the incidence of pulmonary embolism.