Multi-site Comprehensive Noninvasive Optical Shock Monitor

Shock caused by some reasons(such as hemorrhage, trauma, etc.) can lead to acute blood circulation disorder, a serious shortage of microcirculation perfusion, as well as vital organs function and metabolism of complex structural damage severe systemic pathological process. It is the most common complication in clinical serious diseases. This research applied the near-infrared spectroscopy to develop a multi-site comprehensive noninvasive optical shock monitor, and conducted the clinical trials. This paper introduced the home and abroad status quo about shock, and I found there is no continuous, real-time, non-invasive monitor of the state of shock. Combining with the NIRS in the oxygen saturation monitor, I proposed to design a technology program that can monitor shock patients continuously, real-time, non-invasively monitoring. I study the most classical oxygen saturation detection theory-pulse oximetry algorithm, and found the algorithm is not suitable to monitor the shock patients. I list the two algorithm which are not affect by poor peripheral circulation and peripheral hypoperfusion, the one is the relative amount of tissue blood oxygen saturation algorithms, another is the absolute amount of tissue blood oxygen saturation algorithms. According to the preliminary plans, I did the Monte Carlo simulation of optical of the monitoring positions. Taking the neck area simulation for example, the best source-detector distance parameter which is important for the monitor probe design was been given. After doing some research of the instrument components, I determined the selection of light source, detector, the main controller unit, analog to digital converter unit, light source drive and so on and used Altium Designer 14 to design the probe circuits and the control circuit. In the Qt platform and combined with the third-party graphics library Qwt, I developed the PC program to achieve real-time display and storage of data. When the monitor development completed, I validated instrument key performance indicators, such as the system response consistency, backlight interference, dark noise, and sensitivity. Finally, in Shanghai Xinhua Hospital conducted pre-clinical trials to monitor the patients on the verge of shock. After data analysis, We found that the monitor can really warn shock severity, also found that oxygen parameters of jugular central region more effectively in monitoring the patient’s condition trends. During pre-clinical trials we verify the effects of central venous filling degree by changes in body position and maybe provide a new idea for further research.