The Relationship Of Alcohol Drinking With Serum Lipid Levels In Lianyungang Rural Population With Hypertension

Objective To investigate the association between alcohol drinking and blood lipid levels as well as the influencing factors in Lianyungang rural population with hypertension.Methods An epidemiological investigation was conducted,from May 2008 to July 2009, in residents aged 45 to 75 who were enrolled randomly in rural areas of Lianyungang. Baseline data collection, including alcohol drinking status, was conducted by trained research staff using a standardized questionnaire designed specifically for the study. Serum total cholesterol(TCHO), triglyceride(TG) and high-density lipoprotein cholesterol(HDL-C) were measured using automatic clinical analyzers(Beckman Coulter). Low-density lipoprotein cholesterol(LDL-C) was estimated by the Friedewald formula. Multivariate linear regression models were applied to evaluate the relation between alcohol drinking status and blood lipid levels.Results A total of 14326 participants were included in the final analysis, 5574(38.9%)were males and 8752(61.1%) were female. The average age of the total population were 59.6±7.6. The total alcohol drinking rate was 22.8%, male alcohol drinking rate was 53.5%, and 3.3% for female. After the adjustment for age, body mass index, blood pressure, fasting glucose, smoking and physical activity levels, compared to never alcohol drinkers, current alcohol drinkers showed significantly increased concentrations of serum TCHO(β=15.58, SE=1.30, P<0.001), HDL-C(β=8.01, SE=0.43, P<0.001) and LDL-C(β=7.71, SE=1.17,P<0.001), but had no significant effect on the TG levels(β=-0.71, SE=1.88, P=0.704) for male. The current alcohol drinkers showed significantly increased concentrations of serum TCHO(β=9.90,SE=2.78,P<0.001),HDL-C(β=4.43,SE=0.80,P<0.001)and LDL-C(β=7.55,SE=2.53,P=0.003),but decreased concentrations of TG levels(β=-10.49,SE=3.95,P =0.008). Among the different stratification of age, blood pressure, diabetes, alcohol drinking and blood lipid levels had no significant relationships(interaction P values were greater than 0.10). Furthermore, a greater association between alcohol assumption and the increase of TCHO(versus participants without diabetes, P for interaction <0.001) or LDL-C(versus participants without diabetes, P for interaction=0.001) levels was observed in participants with diabetes for male. Multiple linear regression of drinking years and blood lipid levels shows that there was time-effects relationship of drinking years and cholesterol in male. The longer drinking years, the cholesterol is higher. There was no significant association between drinking years and triglyceride.Conclusion In the male population, alcohol drinking was significantly associated with increased total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels. There was no significant association between alcohol drinking and the level of triglyceride. The longer drinking years, the cholesterol is higher. There was a greater association between alcohol assumption and cholesterol in population with diabetes. In the female population, alcohol drinking was significantly associated with increased total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels, but decreased the level of triglyceride.