Chinese Medicine Extract 6-0-angeloylplenolin And Evodiamine Function And Molecular Mechanism Of Lung Cancer Treatment

Worldwide, lung cancer is the incidence and mortality are high; especially in China, the incidence and mortality of lung cancer are the highest in the top class; therefore the urgent need to explore the methods of treatment of lung cancer.Lung cancer is a general designation of lung cancer, but cancer of the lungs can concrete can be divided into non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and non small cell lung cancer and can be further divided into adenocarcinoma, squamous cell carcinoma and large cell carcinoma, in addition to clinical and divided into 0,â… , â…¡, â…¢, â…£ phase.Lung cancer is a systemic disease, has complex causes and clinical features, the different types of lung cancer will require individualized treatment, the main treatment method of radiotherapy and chemotherapy, surgery and in recent years, the high-speed development of small molecule inhibitors. However, these treatments have certain limitations, so scientists will look to the magnificent treasure house of traditional Chinese medicine, hope can from Chinese herbal medicine extract natural compounds in the treatment of lung cancer. This paper mainly includes two aspects:1.the natural small molecule compounds Centipeda minima effective components of 6-O-angeloylplenolin(6-OAP) on lung cancer cell function, and of epidermal growth factor receptor(EGFR) inhibiting agent gefitinib synergism. Gefitinib is discovered in 1990 of an epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI), after the study found gefitinib can inhibit lung cancer cell growth, metastasis and angiogenesis, and induce the apoptosis of tumor cells, applicable in the treatment of previously received chemotherapy for locally advanced and metastatic non small cell lung cancer.Laboratory studies have found that the molecular mechanism of 6-OAP targeted SCF complex induces cell cycle G2/M arrest, and has the Pharmacokinetic characteristics. Further we found 6-OAP of kinds of lung cancer cell line has an inhibitory effect, but also has significant anti-cancer effect in mouse model of Lung cancer, previous studies found thatlt was found to have inhibitory effect on many kinds of tumors, and can increase the sensitivity of dexamethasone on multiple myeloma.Thus, we explored whether 6-OAP and gefitinib in combination with gefitinib overcome resistance. Gefitinib is the epidermal growth factor receptor tyrosine kinase inhibitors, which inhibit the downstream signaling pathway,6-OAP by acting on the SCF complexes can also effect many cellular pathways, combined with 6-OAP found with gefitinib by comparing compared to celecoxib two drugs alone inhibited cell proliferation better effect, using software to calculate synergy index.So we chose lung adenocarcinoma cell line A549 cells were used as the main object of our study, found that 6-OAP used in combination with gefitinib can significantly inhibit the ability of invasion and metastasis know, and there are statistically significant, further investigation found 6-OAP joint gefitinib in significantly reduced p-AKT, p-ERK protein level, etc., to enhance the anti-tumor effect of gefitinib Nepal for gemfibrozil may provide a new treatment for patients resistant to Nepal for Chinese medicine combined with Western medicine treatment of cancer may be increased.2.Advantages medicine treatment of disease is relatively clear mechanism for the disease is relatively clear, and advantages of Chinese medicine is that after thousands of years of heritage, for the treatment of the disease has its own set of complete system, but the specific mechanism is unclear, this prevents Chinese medicine recognized worldwide. Thus sieved active ingredient in traditional Chinese medicine is an urgent need, the laboratory has many Herbal Extracts, we use a variety of cancer cell lines can be used to screen take medicine to fight cancer cell lines-extract. Results We found a variety of active ingredients to fight cancer, Evo is a new small molecule natural compound found in our recent, preliminary studies have found that Evo can inhibit tumor cell proliferation and induce cell in G2/M phase arrest, follow-up studies are in progress.