Study On The Relationship Between Vascular Endorthelium Function And Metabolic Syndrome

Objective: To investigate whether there are differences in endothelial function in nonalcoholic fatty liver disease(NAFLD) patients with or without metabolic syndrome(MetS). To study the influencing factors of endothelial function in patients with NAFLD. Methods: Collected the NAFLD patients in the First Affiliated Hospital of Xinjiang Medical University during January 2015 to October 2015, except the patients with end-stage organ damage of atherosclerosis such as coronary heart disease and cerebrovascular disease. According to whether the patients had MetS, the patients were divided into NAFLD with MetS group(A group) and NAFLD without MetS group(B group). Vascular endothelial function was reviewed and reactive hyperemia index(RHI) was calculated by using peripheral arterial tension(PAT) detection with Endo-PAT2000(Itamar Medical Inc.Caesarea, Isarel). The risk factor about endothelial dysfunction in NAFLD patients was analyzed by Logistic regression. Results: 91 cases were collected, including 52 cases in group A, 39 cases in group B. RHI in group A(1.63±0.29), RHI groupB(1.81±0.29), the difference between the two groups was statistically significant(P<0.01). The levels of BMI, systolic blood pressure, fasting plasma glucose(FPG) and triglycerides increased significantly in group B compared with group A(P<0.05). The levels of low density lipoprotein cholesterol, aspartate amino transferase and alanine aminotransferase(ALT) increased significantly in group A compared with group B(P<0.05). FPG、free fatty acid(FFA) and ALT were the risk factors of endothelial dysfunction in NAFLD patients(P<0.05, OR=1.338、5.578、1.040). Conclusion: The RHI level in NAFLD patients is slightly lower than the general population standard which were reported in literatures.The RHI in NAFLD patients is lower than the NAFLD with MetS. FPG、FFA and ALT were the risk factors of endothelial dysfunction in NAFLD patients.