Clinical Characteristics Of 24-hour Ambulatory Blood Pressure Variation In Patients With Chronic Kidney Disease

Objective:To investigate the variation characteristics of 24 hours ambulatory blood pressure(ABP) in patients with chronic kidney disease(CKD) at different stages of renal function. Methods:A total of 362 CKD patients from the First Hospital of Xinjiang Medical University for the study, according to the glomerular filtration rate(GFR) were divided into 5 groups: CKD1 group 101 cases; CKD2 group 83 cases; CKD3 group of 90cases; 56 cases of CKD4 group; CKD5 group of 32 cases. All of whom carried ambulatory blood pressure monitoring(ABPM) to measure ambulatory blood pressure parameters,circadian rhythm and clinical data.Results:(1)With the decline in renal function, average24 h, daytime and nighttime systolic blood pressure(SBP) and pulse pressure became higher in CKD patients;(2)Total of 53.0% CKD patients were non-dipper BP pattern,24.3% patients were reversed dipper BP pattern,and dipper BP pattern was only20.7%,the proportion of dipper blood pressure gradually decreased with advanced CKD;(3)Compared with non-dipper and reversed dipper BP pattern group,patients with dipper BP pattern had higher average nighttime systolic blood pressure(SBP),diastolic blood pressure(DBP) and pulse pressure,lower the nighttime blood pressure decrease rat.(4)Microalbuminuria(MAU)>300mg/24 h compared to 30mg/24h≤MAU<300mg/24 h,systolic blood pressure were increased. Conclusion: With the decline of renal function in patients with CKD,the hypertension increased and the majority of hypertension are non-dipper and reversed dipper BP pattern,circadian rhythm appears at the early stage of CKD,systolic and diastolic blood pressure with microalbuminuria levels increased.