Effect Of Bronchoscopic Interventional Therapy Combined With Local Application Of Topical Application With Paclitaxel In The Study Of Benign Cicatricial Airway Stenosis

Objective To assess bronchoscope interventional therapy combined with local injection of paclitaxel in the treatment of benign airway stenosis scar efficacy and safety.Methods 32 cases of benign airway stenosis scar will be divided into groups of paclitaxel, mitomycin group and the control group, eight cases in which the paclitaxel group, mitomycin group of 12 patients in the control group of 12 patients, paclitaxel and mitomycin prime group with tracheal endoscopic intervention, including balloon angioplasty, electrical excision, freezing, and airway stenosis local injection of taxol or mitomycin, the control group using conventional bronchoscope intervention. Follow-up of six months, measured before and after treatment of cross-sectional area, calculated airway stenosis airway diameter, dyspnea index before and after treatment were observed airway stenosis local application of paclitaxel, mitomycin efficacy and safety.Results Before and after the treatment of airway cross-sectional area and diameter stenosis comparison shows that paclitaxel group,efficacy of mitomycin group than in the control group the efficacy of airway cross-sectional area and diameter differences before and after the three groups of patients was statistically significant(P<0.05),paclitaxel group compared with the efficacy of mitomycin group showed no significant difference(P < 0.05),to improve the three groups of patients before and after treatment difference dyspnea index was statistically significant(P < 0.05),paclitaxel,silk mitomycin group within six months again interventional treatment also significantly reduced the number of times,the difference was not statistically significant(P<0.05).Paclitaxel group,MMC group were no drug-relatedcomplications occur during the observation period.Conclusion Partial airway stenosis Paclitaxel inhibits airway scarring, and less conventional way interventional therapy significantly prolonged benign airway stenosis scar restenosis time, efficacy and safety are good.