Preliminary Simulation Study Of Creation Of Biological Pacemaker Based On Actrial Cell

Currently, the main clinical treatment for slow arrhythmia is the artificial pacemaker implantation method, which still has its shortcomings when in practical use although modern pacing technology has made remarkable development. With the development of biotechnology, the application of biological pacing in treating slow arrhythmia become possible. As we know, the main reason for sick sinus syndrome is the decrease of P pacemaker cells having pacing function, if we can make atrial myocytes cells as the new pacing sites by biotechnological means to replace damaged cells, and form a good electrical-mechanical connection, then the pacing function can be restored.As the necessary complement to clinical research, modeling and simulation is very popular for researchers because of its convenience and repeatability. In order to study the feasibility of atrial myocytes as new pacing sites, this thesis will deeply analyze the pacing mechanism of sinoatrial node cells, and will establish the pacing action potential based on the model of atrial myocytes to provide model support and theoretical analysis for the biological pacemaker study. The modeling and simulation of ion flows associated with the sinus node pacemaker cells in this thesis mainly includes the following aspects:1) Have a review of the physiological characteristics of the cardiac sinus node cells and the physiology characteristics of atrial myocytes, and make in-depth analysis in the formation mechanism of sinoatrial node cells spontaneous action potential;2) Simulation of the hyperpolarization-activated pacemaker current, T-type calcium current, L-type calcium currents and the impact of delayed finishing potassium currents on the action potential of sinoatrial node cells;3) Simulation of hyperpolarization-activated pacemaker current, T-type calcium current, L-type calcium currents and the impact of delayed finishing potassium current on atrial myocytes, and make the atrial muscle cells have spontaneous action potentials by modifying the parameters in the model and observe changes in atrial myocytes.4) Analysis of the feasibility of the atrial myocytes as new pacing sites.